Document Detail

Plasma concentration--effect relationships for felodipine: a meta analysis.
MedLine Citation:
PMID:  1385566     Owner:  NLM     Status:  MEDLINE    
The plasma concentration versus antihypertensive effect relationship for the calcium antagonist felodipine was investigated in 67 patients with hypertension and 21 healthy subjects by use of the Emax model. No consistent effect of felodipine on blood pressure was observed in the healthy subjects. In patients with hypertension the plasma drug concentration and blood pressure versus time curves mirrored each other, indicating a close relationship between concentration and effect. The maximum effect (Emax) model fitted the diastolic blood pressure data of most patients, but the model was less often applicable in patients with low initial diastolic blood pressure levels. The average Emax values and the plasma felodipine concentration needed to obtain 50% of Emax for the patients with hypertension were 29 mm Hg and 8 nmol/L, respectively. The Emax values increased with increasing initial diastolic blood pressure levels but were similar in patients with high and low plasma felodipine concentrations. Age had negligible influence on the antihypertensive response to felodipine when compensation was made for the plasma concentrations.
E Blychert; B Edgar; D Elmfeldt; T Hedner
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical pharmacology and therapeutics     Volume:  52     ISSN:  0009-9236     ISO Abbreviation:  Clin. Pharmacol. Ther.     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1992-08-10     Completed Date:  1992-08-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372741     Medline TA:  Clin Pharmacol Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  80-9     Citation Subset:  AIM; IM    
Department of Clinical Pharmacology, Sahlgrenska University Hospital, Göteborg, Sweden.
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MeSH Terms
Age Factors
Antihypertensive Agents / pharmacology*,  therapeutic use
Blood Pressure / drug effects*
Felodipine / blood,  pharmacology*,  therapeutic use
Hypertension / drug therapy
Meta-Analysis as Topic
Middle Aged
Models, Statistical
Time Factors
Reg. No./Substance:
0/Antihypertensive Agents; 72509-76-3/Felodipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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