| Plasma concentration--effect relationships for felodipine: a meta analysis. | |
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MedLine Citation:
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PMID: 1385566 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The plasma concentration versus antihypertensive effect relationship for the calcium antagonist felodipine was investigated in 67 patients with hypertension and 21 healthy subjects by use of the Emax model. No consistent effect of felodipine on blood pressure was observed in the healthy subjects. In patients with hypertension the plasma drug concentration and blood pressure versus time curves mirrored each other, indicating a close relationship between concentration and effect. The maximum effect (Emax) model fitted the diastolic blood pressure data of most patients, but the model was less often applicable in patients with low initial diastolic blood pressure levels. The average Emax values and the plasma felodipine concentration needed to obtain 50% of Emax for the patients with hypertension were 29 mm Hg and 8 nmol/L, respectively. The Emax values increased with increasing initial diastolic blood pressure levels but were similar in patients with high and low plasma felodipine concentrations. Age had negligible influence on the antihypertensive response to felodipine when compensation was made for the plasma concentrations. |
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Authors:
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E Blychert; B Edgar; D Elmfeldt; T Hedner |
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Publication Detail:
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Type: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical pharmacology and therapeutics Volume: 52 ISSN: 0009-9236 ISO Abbreviation: Clin. Pharmacol. Ther. Publication Date: 1992 Jul |
Date Detail:
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Created Date: 1992-08-10 Completed Date: 1992-08-10 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372741 Medline TA: Clin Pharmacol Ther Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 80-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Clinical Pharmacology, Sahlgrenska University Hospital, Göteborg, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Antihypertensive Agents / pharmacology*, therapeutic use Blood Pressure / drug effects* Felodipine / blood, pharmacology*, therapeutic use Female Humans Hypertension / drug therapy Male Meta-Analysis as Topic Middle Aged Models, Statistical Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 72509-76-3/Felodipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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