Document Detail

Plasma colloid osmotic pressure and total protein in horses during colic surgery.
MedLine Citation:
PMID:  17696975     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the changes in colloid osmotic pressure (COP) in horses undergoing surgery for colic. STUDY DESIGN: Prospective clinical evaluation. ANIMALS: Twenty-nine adult horses presented for emergency laparotomy. METHODS: Horses were premedicated with intravenous (IV) xylazine and anesthesia was induced with ketamine, diazepam and guaifenesin and was maintained with isoflurane as required. Lactated Ringer's solution (LRS) was given to all horses during anesthesia. Blood was collected in heparin before, and every 30 minutes during, anesthesia to measure COP, total protein concentration (TP), osmolality, packed cell volume, electrolytes, glucose and lactate. In addition, COP was estimated using different formulas previously described for horses. RESULTS: Before anesthesia, COP and TP were 18.7 +/- 2.2 mmHg (2.49 +/- 0.29 kPa) and 6.3 +/- 0.7 g dL(-1), respectively. The horses received a mean +/- SD of 19.5 +/- 3.9 mL kg(-1) hour(-1) (range 15-25 mL kg(-1)hour(-1)) of LRS during anesthesia. The COP and TP decreased linearly (R(2) = 0.99, p < 0.01) during anesthesia and reached the lowest point at the end of anesthesia with a COP of 11.6 +/- 1.6 mmHg (1.55 +/- 0.21 kPa) and TP of 4.4 +/- 0.4 g dL(-1). The Pearson correlation coefficient for COP versus TP was r(2) = 0.78. Calculation of COP from TP concentrations showed that two formulas could predict COP to within 1 mmHg (0.13 kPa) (Thomas & Brown 1992; Boscan et al. 2007). CONCLUSIONS AND CLINICAL RELEVANCE: Colloid osmotic pressure, like TP, decreased greatly over the course of crystalloid fluid infusion during anesthesia for laparotomy in horses with colic. This change may predispose the animal to tissue edema with subsequent morbidity.
Pedro Boscan; Eugene P Steffey
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Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2007-08-13
Journal Detail:
Title:  Veterinary anaesthesia and analgesia     Volume:  34     ISSN:  1467-2987     ISO Abbreviation:  Vet Anaesth Analg     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-11-05     Completed Date:  2008-01-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100956422     Medline TA:  Vet Anaesth Analg     Country:  England    
Other Details:
Languages:  eng     Pagination:  408-15     Citation Subset:  IM    
Veterinary Medical Teaching Hospital, University of California, Davis, CA, USA.
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MeSH Terms
Anesthesia / veterinary*
Anesthetics, Inhalation / administration & dosage,  pharmacology*
Anesthetics, Intravenous / administration & dosage,  pharmacology*
Blood Proteins / metabolism*
Colic / surgery,  veterinary
Colloids / metabolism*
Horse Diseases / blood,  surgery
Horses / blood*
Infusions, Intravenous / veterinary
Isoflurane / administration & dosage,  pharmacology*
Isotonic Solutions / administration & dosage
Laparotomy / veterinary
Osmotic Pressure / drug effects*
Prospective Studies
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Anesthetics, Intravenous; 0/Blood Proteins; 0/Colloids; 0/Isotonic Solutions; 26675-46-7/Isoflurane; 8022-63-7/Ringer's lactate

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