| Plasma citrulline is a marker of absorptive small bowel length in patients with transient enterostomy and acute intestinal failure. | |
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MedLine Citation:
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PMID: 19744750 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND & AIMS: Small bowel disruption is often complicated by acute intestinal failure and can be corrected by chyme reinfusion (CR). Plasma citrulline ([Cit]) is a biomarker of the enterocyte mass. Our aim was to determine whether [Cit] could be a marker of absorptive intestinal mass or function by assessing whether CR could affect intestinal absorptive function and [Cit]. METHODS: Twenty-six patients with small bowel disruption and double enterostomy were treated with CR. Fecal wet weight, nitrogen and fat absorption, parenteral nutrition delivery and [Cit] were measured before and after the initiation of CR with a median follow-up of 30 days. RESULTS: CR decreased the intestinal wet weight output (median+/-IQ, 2384+/-969 vs. 216+/-242mLd(-1), P<0.0001) and parenteral nutrition dependence (65% vs. 8%, P<0.01). CR was associated with a rise in net nitrogen and fat digestive absorption and [Cit] (17.0+/-10.0 vs. 31.0+/-12.0micromolL(-1), P=0.0001). Before the initiation of CR, [Cit] correlated positively with the absorptive post-duodenal small bowel length (r=0.39, P=0.04), but not with the total post-duodenal small bowel length (r=0.11, P=0.60). CONCLUSION: CR allows for a dramatic improvement of intestinal absorptive function and a near doubling in [Cit] level. [Cit] is not a marker of overall intestinal mass, but of the absorptive small bowel function. |
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Authors:
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Denis Picot; Laurence Garin; Florence Trivin; Michel P Kossovsky; Dominique Darmaun; Ronan Thibault |
Publication Detail:
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Type: Controlled Clinical Trial; Journal Article Date: 2009-09-09 |
Journal Detail:
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Title: Clinical nutrition (Edinburgh, Scotland) Volume: 29 ISSN: 1532-1983 ISO Abbreviation: Clin Nutr Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-30 Completed Date: 2010-07-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8309603 Medline TA: Clin Nutr Country: England |
Other Details:
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Languages: eng Pagination: 235-42 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. |
Affiliation:
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Service de R?adaptation Digestive et Nutritionnelle, Clinique Saint Yves, 4 rue Adolphe Leray CS54435, Rennes F-35044, France. picot@clinique-styves.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adolescent Adult Aged Biological Markers / blood Body Mass Index Citrulline / blood* Enteral Nutrition / methods Enterocytes / physiology* Enterostomy* Female Gastrointestinal Contents Humans Intestinal Absorption / physiology* Intestinal Diseases / blood*, physiopathology*, surgery Intestine, Small / physiopathology* Male Middle Aged Nutritional Status Severity of Illness Index Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 372-75-8/Citrulline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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