| Plasma cell leukaemia. Diagnostic problems in our experience with 11 cases. | |
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MedLine Citation:
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PMID: 6769279 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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11 patients with plasma cell leukaemia (PCL) are reported. Diagnostic clinical, haematological, immunological, biochemical and electron microscopical (TEM) data were analysed and compared to the largest series of PCL cases reported in the literature. Special attention was paid to four facets of this disease: (a) the clinical picture at admission; (b) the frequency of PCL; (c) the production of M components in relation to the maturity and type of the asynchronous plasma cells, and (d) the diagnostic problems of this entity of acute leukaemia of the afferent limb of the B lymphocyte transformation. In this series PCL emerges as a distinct clinical entity: patients are severely anaemic, hepatosplenomegaly is prominent, bone lessions are uncommun, but if present are usually non-osteolytic, and the response to treatment with an alkylating agent and glucocorticoid is poor. The diagnosis is difficult since the circulating plasma cells may have morphological features which only allows the diagnosis to be made after the TEM examination. If the peripheral blood of cases of acute leukaemias and immunocytic dyscrasias is routinely examined by TEM, PCL appears to be a not uncommon variant of plasma cell dyscrasia--in the present study it was 11%. |
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Authors:
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V A Toma; F P Retief; G M Potgieter; J D Anderson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta haematologica Volume: 63 ISSN: 0001-5792 ISO Abbreviation: Acta Haematol. Publication Date: 1980 |
Date Detail:
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Created Date: 1980-07-22 Completed Date: 1980-07-22 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0141053 Medline TA: Acta Haematol Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 136-45 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult African Continental Ancestry Group Aged Anemia, Macrocytic / epidemiology B-Lymphocytes / physiology Blood Viscosity Female Hemorrhagic Disorders / epidemiology Hepatomegaly / epidemiology Humans Immunoglobulins / analysis Leukemia, Plasma Cell / blood, diagnosis*, epidemiology Leukocyte Count Lymphocyte Activation Male Middle Aged Osteoporosis / epidemiology Plasma Cells / pathology Serum Albumin / analysis Sex Factors Splenomegaly / epidemiology |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulins; 0/Serum Albumin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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