Document Detail


Plasma catecholamines and response to exercise in 6-hydroxydopamine-treated dogs.
MedLine Citation:
PMID:  6817903     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Plasma catecholamine (CA; picograms per millilitre) concentrations were measured simultaneously with heart rate (HR, beats per minute) during short-duration exercise, and with plasma glucose, lactate, and free fatty acid (FFA) concentrations (millimoles per litre) during long-duration exercise, in control dogs (N-dogs) and in sympathectomized dogs (S-dogs) with 6-hydroxydopamine (50 mg X kg-1). At rest, higher plasma CA in S-dogs (690 +/- 90 vs. 320 +/- 60) was associated with higher HR (126 +/- 3 vs. 90 +/- 5), plasma glucose (6.4 +/- 0.2 vs. 5.1 +/- 0.2), lactate (2.9 +/- 0.2 vs. 1.6 +/- 0.2), and FFA concentrations (1.08 +/- 0.11 vs. 0.81 +/- 0.11). During short-duration exercise a normal HR response in S-dogs (226 +/- 9 vs. 228 +/- 8) was dependent upon larger than normal plasma CA values (4280 +/- 680 vs. 1990 +/- 360). Metabolic adjustments to long-duration exercise were impaired in S-dogs as evidenced by the higher plasma glucose and lactate concentrations (8.2 +/- 0.5 and 5.5 +/- 0.3 vs. 6.4 +/- 0.4 and 4.6 +/- 0.3) and the lower plasma FFA concentration (0.66 +/- 0.16 vs. 1.20 +/- 0.09). These occurred despite a normal plasma CA response in S-dogs (6850 +/- 1450 vs. 8740 +/- 1680). Following chemical sympathectomy the adrenal medulla can compensate to ensure an adequate heart rate response to short-duration exercise, but not to ensure adequate metabolic adjustments to prolonged exercise.
Authors:
F Péronnet; R Nadeau; J de Champlain; A Imbach
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  60     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  1982 Sep 
Date Detail:
Created Date:  1983-03-11     Completed Date:  1983-03-11     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  1219-24     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adrenal Medulla / physiology
Animals
Catecholamines / blood*
Dogs
Heart Rate
Hydroxydopamines / pharmacology
Oxidopamine
Physical Exertion*
Sympathectomy, Chemical
Sympathetic Nervous System / physiology*
Chemical
Reg. No./Substance:
0/Catecholamines; 0/Hydroxydopamines; 1199-18-4/Oxidopamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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