| Plasma catecholamines in pre- and in postmenopausal women with mild to moderate essential hypertension. | |
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MedLine Citation:
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PMID: 9175567 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The sympathetic nervous system (SNS) is thought to play an important role in the pathogenesis of essential hypertension and many studies have established a relationship between plasma levels of norepinephrine (NE) and epinephrine (E) and sympathetic nervous activity (SNA). Furthermore, it has been suggested that climacteric women are more exposed to psychosocial stress which can produce a transient rise in blood pressure (BP) and, with time, determine a hypertensive state. Plasma NE and E levels were measured at rest and after physiological stimulation (head-up tilt test) in 20 hypertensive (BP: 146 +/- 13/101 +/- 4 mm Hg) and in 20 normotensive women (BP: 132 +/- 7/85 +/- 4 mm Hg). Women in each of these two groups were further subdivided according to their climacteric status (10 premenopausal and 10 postmenopausal women). No difference in NE values at rest was found between groups and subgroups. During head-up tilt test, Ln NE plasma values increased in normotensive and hypertensive groups; the rise was significantly higher in hypertensive than in normotensive women (P < 0.01). In climacteric subgroups, Ln NE appeared markedly increased above resting levels in pre- and postmenopausal hypertensive women when their position was changed from supine to upright (P < 0.01). Since high plasma NE levels after stimulation (head-up tilt) are associated with sympathetic overactivity, we conclude that SNA is involved in the pathogenesis of essential hypertension in climacteric women. |
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Authors:
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A S Villecco; D de Aloysio; D Radi; G Sprovieri; A M Bargossi; G Grossi; C Gueli; M Salgarello; G Cavrini |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of human hypertension Volume: 11 ISSN: 0950-9240 ISO Abbreviation: J Hum Hypertens Publication Date: 1997 Mar |
Date Detail:
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Created Date: 1997-07-15 Completed Date: 1997-07-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8811625 Medline TA: J Hum Hypertens Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 157-62 Citation Subset: IM |
Affiliation:
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Istituto di Clinica Medica Generale e Terapia Medica, Università di Bologna, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Pressure Epinephrine / blood* Female Heart Rate Humans Hypertension / blood*, etiology, physiopathology Middle Aged Norepinephrine / blood* Postmenopause / blood* Premenopause / blood* Sympathetic Nervous System / metabolism, physiopathology |
| Chemical | |
Reg. No./Substance:
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51-41-2/Norepinephrine; 51-43-4/Epinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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