Document Detail

Plasma catecholamines in pre- and in postmenopausal women with mild to moderate essential hypertension.
MedLine Citation:
PMID:  9175567     Owner:  NLM     Status:  MEDLINE    
The sympathetic nervous system (SNS) is thought to play an important role in the pathogenesis of essential hypertension and many studies have established a relationship between plasma levels of norepinephrine (NE) and epinephrine (E) and sympathetic nervous activity (SNA). Furthermore, it has been suggested that climacteric women are more exposed to psychosocial stress which can produce a transient rise in blood pressure (BP) and, with time, determine a hypertensive state. Plasma NE and E levels were measured at rest and after physiological stimulation (head-up tilt test) in 20 hypertensive (BP: 146 +/- 13/101 +/- 4 mm Hg) and in 20 normotensive women (BP: 132 +/- 7/85 +/- 4 mm Hg). Women in each of these two groups were further subdivided according to their climacteric status (10 premenopausal and 10 postmenopausal women). No difference in NE values at rest was found between groups and subgroups. During head-up tilt test, Ln NE plasma values increased in normotensive and hypertensive groups; the rise was significantly higher in hypertensive than in normotensive women (P < 0.01). In climacteric subgroups, Ln NE appeared markedly increased above resting levels in pre- and postmenopausal hypertensive women when their position was changed from supine to upright (P < 0.01). Since high plasma NE levels after stimulation (head-up tilt) are associated with sympathetic overactivity, we conclude that SNA is involved in the pathogenesis of essential hypertension in climacteric women.
A S Villecco; D de Aloysio; D Radi; G Sprovieri; A M Bargossi; G Grossi; C Gueli; M Salgarello; G Cavrini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of human hypertension     Volume:  11     ISSN:  0950-9240     ISO Abbreviation:  J Hum Hypertens     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-07-15     Completed Date:  1997-07-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  157-62     Citation Subset:  IM    
Istituto di Clinica Medica Generale e Terapia Medica, Università di Bologna, Italy.
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MeSH Terms
Blood Pressure
Epinephrine / blood*
Heart Rate
Hypertension / blood*,  etiology,  physiopathology
Middle Aged
Norepinephrine / blood*
Postmenopause / blood*
Premenopause / blood*
Sympathetic Nervous System / metabolism,  physiopathology
Reg. No./Substance:
51-41-2/Norepinephrine; 51-43-4/Epinephrine

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