| Plasma catecholamines and N-terminal proBNP in patients with acute myocardial infarction undergoing primary angioplasty. Relation to left ventricular function and clinical outcome. | |
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MedLine Citation:
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PMID: 12545304 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Neither profiles nor prognostic values of neurohormonal markers have been prospectively evaluated in patients with acute myocardial infarction (AMI) undergoing primary angioplasty. METHODS AND RESULTS: In 118 consecutive patients with AMI undergoing successful reperfusion (TIMI 2 and 3) by primary angioplasty, plasma concentrations of norepinephrine, epinephrine and N-terminal proBNP (NT-proBNP) were measured before, 60 min and 10 days after angioplasty. Catecholamine concentrations (mean+/-SEM) rose to a maximum in the first hour after angioplasty (norepinephrine: 602+/-44 ng/L, epinephrine: 213+/-24 ng/L) and returned to normal at day 10. Conversely, NT-proBNP levels maintained a further increase from 799+/-44 pmol/L at baseline to 924+/-54 pmol/L at day 10. A NT-proBNP concentration above median at 60 min post-angioplasty predicted major adverse cardiac events (n=27) during the 18-36 month follow-up with an odds ratio of 5.9 (1.7-20.3) and was superior to catecholamines, to left ventricular ejection fraction and to other established postinfarction risk markers. CONCLUSIONS: In a low-risk cohort of patients with AMI undergoing successful reperfusion therapy, plasma NT-proBNP concentrations are elevated for at least ten days. The prognostic value of early plasma NT-proBNP should be further evaluated concerning its ability to facilitate risk stratification of infarct patients. |
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Authors:
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F Hartmann; V Kurowski; A Maghsoudi; T Kurz; M Schwarz; H Bonnemeier; R Tölg; D Jain; U Wiegand; H Katus; G Richardt |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Zeitschrift für Kardiologie Volume: 92 ISSN: 0300-5860 ISO Abbreviation: Z Kardiol Publication Date: 2003 Jan |
Date Detail:
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Created Date: 2003-01-24 Completed Date: 2003-06-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0360430 Medline TA: Z Kardiol Country: Germany |
Other Details:
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Languages: eng Pagination: 73-81 Citation Subset: IM |
Affiliation:
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Medizinische Klinik II, UK Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany. hartmann@medinf.mu-luebeck.de |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angioplasty, Transluminal, Percutaneous Coronary* Epinephrine / blood* Female Follow-Up Studies Humans Male Middle Aged Myocardial Contraction / physiology* Myocardial Infarction / blood, mortality, therapy* Natriuretic Peptide, Brain Nerve Tissue Proteins / blood* Norepinephrine / blood* Peptide Fragments / blood* Prognosis Recurrence Risk Assessment Stroke Volume / physiology* Survival Analysis Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Nerve Tissue Proteins; 0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain; 51-41-2/Norepinephrine; 51-43-4/Epinephrine |
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