Document Detail

Plasma catecholamine levels in the coronary sinus, the left renal vein and peripheral vessels in healthy males at rest and during exercise.
MedLine Citation:
PMID:  716987     Owner:  NLM     Status:  MEDLINE    
Noradrenaline and adrenaline were determined in blood samples from the brachial vein, the brachial artery, the left renal vein and the femoral vein in 6 healthy males (aged 23-35 y). In 3 of the subjects catecholamines were determined also in blood from the coronary sinus. All samples were taken simultaneously in supine postion after 30 min of rest and then in connection with exercise in supine position using a bicycle ergometer, firstly with a work load of 50 W for 9 min and secondly with a work load of 150 W for the same period of time. Under resting conditions the catecholamine levels were about the same at all locations, the mean for noradrenaline being 1.59 nmol/1 with a range of 1.30-2.11 nmol/1 and for adrenaline 0.46 nmol/1 and 0.23-0.65 nmol/1, respectively. At 50 W the noradrenaline concentration increased significantly in the brachial artery, the left renal vein and the femoral vein, whereas adrenaline increased significantly only in the femoral vein. At 150 W the noradrenaline content increased markedly in all samples, especially in the left renal vein (mean increase 13.02 nmol/1) and the coronary sinus (mean increase 13.06 nmol/1). Adrenaline concentration increased significantly in the brachial artery and the femoral vein. At 150 W the mean net output of noradrenaline as estimated from the calculated flows and actual AV-differences amounted to 2.25 nmol/min from the heart and to 0.36 nmol/min from the kidney.
P Manhem; H Lecerof; B Hökfelt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  104     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  1978 Nov 
Date Detail:
Created Date:  1979-01-26     Completed Date:  1979-01-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  364-9     Citation Subset:  IM    
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MeSH Terms
Brachial Artery
Coronary Vessels
Epinephrine / blood*
Femoral Vein
Kidney / metabolism*
Myocardium / metabolism*
Norepinephrine / blood*
Physical Exertion*
Renal Veins
Reg. No./Substance:
51-41-2/Norepinephrine; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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