Document Detail

Plasma catecholamine and haemodynamic responses to surgical endodontic anaesthetic protocols.
MedLine Citation:
PMID:  9206410     Owner:  NLM     Status:  MEDLINE    
The effects of varying clinically relevant patterns of anaesthetic-vasoconstrictor combinations used for periradicular surgery on plasma concentrations of catecholamines and haemodynamic responses was studied in the canine model. Five mongrel dogs were anaesthetized with sodium pentobarbitol. A femoral cannula was inserted to measure central blood pressure and an ECG was used to monitor heart rate and any associated arrhythmias. Femoral venous blood samples were drawn before initial injection and at 3 and 10 min after injections. Plasma catecholamine concentrations were determined using high pressure liquid chromatography (HPLC). Injection protocols used three time periods, 30, 60 and 90 s, with solutions containing 1:100,000 and 1:50,000 adrenaline. No significant changes in heart rates or presence of arrhythmias were noted over the experimental protocol. Catecholamine levels in pico moles mL-1 were within the normal range at the 3-min sample level. At the 10-min sample time there was a more erratic range of concentrations, with most samples within the normal range. This may have been due to endogenous release of catecholamines in specific animals. The data identified trends in both the haemodynamic parameters and plasma catecholamine levels that can legitimately support the careful use of higher levels of a vasoconstrictor when patient profiles and surgical needs dictate.
J L Gutmann; L W Frazier; B Baron
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  International endodontic journal     Volume:  29     ISSN:  0143-2885     ISO Abbreviation:  Int Endod J     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1997-07-10     Completed Date:  1997-07-10     Revised Date:  2008-08-07    
Medline Journal Info:
Nlm Unique ID:  8004996     Medline TA:  Int Endod J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  37-42     Citation Subset:  D    
Department of Restorative Sciences, Baylor College of Dentistry, Dallas, Texas 75246, USA.
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MeSH Terms
Anesthesia, Dental / methods*
Anesthesia, Local / methods*
Anesthetics, Local
Blood Pressure / drug effects*
Drug Combinations
Epinephrine / blood,  pharmacology*
Heart Rate / drug effects*
Time Factors
Vasoconstrictor Agents / blood,  pharmacology*
Reg. No./Substance:
0/Anesthetics, Local; 0/Drug Combinations; 0/Vasoconstrictor Agents; 137-58-6/Lidocaine; 51-43-4/Epinephrine; 96-88-8/Mepivacaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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