Document Detail

Plasma catecholamine concentration during sedation in ventilated patients requiring intensive therapy.
MedLine Citation:
PMID:  2191018     Owner:  NLM     Status:  MEDLINE    
The effects of isoflurane and midazolam sedation on the catecholamine responses of ventilated patients were studied over a 24-h period. Sixty ventilated patients admitted to our intensive therapy unit were allocated randomly to receive either isoflurane or midazolam sedation. Arterial blood samples for plasma catecholamine concentrations were taken at baseline, 6 h after starting sedation and at the end of the study period. Patients sedated with isoflurane showed a progressive reduction in both adrenaline and noradrenaline concentrations during the period of sedation which reached statistical significance for adrenaline at 6 h (p less than 0.02) and at the end of the study (p less than 0.001). Patients sedated with midazolam showed no significant changes of adrenaline or noradrenaline concentrations. Overall, a more satisfactory degree of sedation was achieved with isoflurane.
K L Kong; S M Willatts; C Prys-Roberts; J T Harvey; S Gorman
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Intensive care medicine     Volume:  16     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  1990  
Date Detail:
Created Date:  1990-07-13     Completed Date:  1990-07-13     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  171-4     Citation Subset:  IM    
Sir Humphrey Davy Department of Anaesthesia, Bristol Royal Infirmary, UK.
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MeSH Terms
Administration, Inhalation
Critical Care*
Epinephrine / blood*
Infusions, Intravenous
Intensive Care Units
Isoflurane / administration & dosage,  pharmacology*,  therapeutic use
Midazolam / administration & dosage,  pharmacology*,  therapeutic use
Middle Aged
Norepinephrine / blood*
Randomized Controlled Trials as Topic
Respiration, Artificial*
Sleep / drug effects*
Stress, Physiological / blood*,  drug therapy,  physiopathology
Reg. No./Substance:
26675-46-7/Isoflurane; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 59467-70-8/Midazolam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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