Document Detail

Plasma carotenoids and vitamin C concentrations and risk of urothelial cell carcinoma in the European Prospective Investigation into Cancer and Nutrition.
MedLine Citation:
PMID:  22952186     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Published associations between dietary carotenoids and vitamin C and bladder cancer risk are inconsistent. Biomarkers may provide more accurate measures of nutrient status.
OBJECTIVE: We investigated the association between plasma carotenoids and vitamin C and risk of urothelial cell carcinoma (UCC) in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition.
DESIGN: A total of 856 patients with newly diagnosed UCC were matched with 856 cohort members by sex, age at baseline, study center, date and time of blood collection, and fasting status. Plasma carotenoids (α- and β-carotene, β-cryptoxanthin, lycopene, lutein, and zeaxanthin) were measured by using reverse-phase HPLC, and plasma vitamin C was measured by using a colorimetric assay. Incidence rate ratios (IRRs) were estimated by using conditional logistic regression with adjustment for smoking status, duration, and intensity.
RESULTS: UCC risk decreased with higher concentrations of the sum of plasma carotenoids (IRR for the highest compared with the lowest quartile: 0.64; 95% CI: 0.44, 0.93; P-trend = 0.04). Plasma β-carotene was inversely associated with aggressive UCC (IRR: 0.51; 95% CI: 0.30, 0.88; P-trend = 0.02). Plasma lutein was inversely associated with risk of nonaggressive UCC (IRR: 0.56; 95% CI: 0.32, 0.98; P-trend = 0.05). No association was observed between plasma vitamin C and risk of UCC.
CONCLUSIONS: Although residual confounding by smoking or other factors cannot be excluded, higher concentrations of plasma carotenoids may reduce risk of UCC, in particular aggressive UCC. Plasma lutein may reduce risk of nonaggressive UCC.
Martine M Ros; H Bas Bueno-de-Mesquita; Ellen Kampman; Katja K H Aben; Frederike L Büchner; Eugene H J M Jansen; Carla H van Gils; Lars Egevad; Kim Overvad; Anne Tjønneland; Nina Roswall; Marie Christine Boutron-Ruault; Marina Kvaskoff; Florence Perquier; Rudolf Kaaks; Jenny Chang-Claude; Steffen Weikert; Heiner Boeing; Antonia Trichopoulou; Pagona Lagiou; Vardis Dilis; Domenico Palli; Valeria Pala; Carlotta Sacerdote; Rosario Tumino; Salvatore Panico; Petra H M Peeters; Inger T Gram; Guri Skeie; José María Huerta; Aurelio Barricarte; José Ramón Quirós; María José Sánchez; Genevieve Buckland; Nerea Larrañaga; Roy Ehrnström; Peter Wallström; Börje Ljungberg; Göran Hallmans; Timothy J Key; Naomi E Allen; Kay-Tee Khaw; Nick Wareham; Paul Brennan; Elio Riboli; Lambertus A Kiemeney
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2012-09-05
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  96     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-21     Completed Date:  2012-12-07     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  902-10     Citation Subset:  AIM; IM    
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MeSH Terms
Ascorbic Acid / blood*,  therapeutic use
Carcinoma, Transitional Cell / blood*,  epidemiology,  etiology,  prevention & control
Carotenoids / blood*,  therapeutic use
Case-Control Studies
Cohort Studies
Diet* / adverse effects
Europe / epidemiology
Follow-Up Studies
Lutein / blood,  therapeutic use
Middle Aged
Papilloma / blood,  epidemiology,  etiology,  prevention & control
Prospective Studies
Urinary Bladder Neoplasms / blood*,  epidemiology,  etiology,  prevention & control
Urothelium / pathology*
Grant Support
11692//Cancer Research UK; G0401527//Medical Research Council; G1000143//Medical Research Council; MC_U106179471//Medical Research Council
Reg. No./Substance:
36-88-4/Carotenoids; PQ6CK8PD0R/Ascorbic Acid; X72A60C9MT/Lutein
Comment In:
Urol Oncol. 2013 Jul;31(5):714-5   [PMID:  23796198 ]

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