| Plasma calcitonin gene-related peptide levels in patients with various hypertensive diseases. | |
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MedLine Citation:
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PMID: 1338081 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To clarify the pathophysiological role of calcitonin gene-related peptide (CGRP) in hypertensive diseases. METHOD: Using a sensitive radioimmunoassay established in our laboratory, plasma CGRP levels were evaluated in control subjects and in patients with essential hypertension, phaeochromocytoma or primary aldosteronism. RESULTS: The CGRP levels in the three hypertensive groups were significantly higher than in normal controls, but no statistically significant difference was observed among CGRP levels in the three hypertensive groups. In the three cases of secondary hypertensives (one patient with phaeochromocytoma and two with primary aldosteronism), a significant decrease in plasma CGRP levels and a marked reduction in blood pressure were observed after adrenalectomy. CONCLUSION: These results suggest that increased plasma CGRP levels in hypertensive patients could be a compensatory reaction to elevated blood pressure. |
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Authors:
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A Masuda; K Shimamoto; Y Mori; M Nakagawa; N Ura; O Iimura |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of hypertension Volume: 10 ISSN: 0263-6352 ISO Abbreviation: J. Hypertens. Publication Date: 1992 Dec |
Date Detail:
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Created Date: 1993-04-08 Completed Date: 1993-04-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1499-504 Citation Subset: IM |
Affiliation:
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Second Department of Internal Medicine, Sapporo Medical College, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Gland Neoplasms
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blood* Adult Blood Pressure / physiology Calcitonin Gene-Related Peptide / blood* Case-Control Studies Female Humans Hyperaldosteronism / blood* Hypertension / blood* Male Middle Aged Pheochromocytoma / blood* Radioimmunoassay |
| Chemical | |
Reg. No./Substance:
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83652-28-2/Calcitonin Gene-Related Peptide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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