Document Detail

Plasma cAMP in normal and abnormal human pregnancy.
MedLine Citation:
PMID:  6256265     Owner:  NLM     Status:  MEDLINE    
Plasma cAMP was determined using the method of Tovey et al. in normal pregnant women with a mean concentration of 18.9 +/- 0.8 pmol/ml (x- +/- SEM). Between weeks 9-12 and 33-36 of gestation, there were two peaks, with a mean cAMP of 22.5 +/- 2.4 which were significantly increased in comparison to the other weeks of pregnancy. Significantly decreased values were found in patients with threatened abortion (weeks 12-28) which terminated in abortion (11.6 +/- 2.4; p < 0.01). In premature labor no differences were found. During therapy with fenoterol there were highly significantly increased plasma cAMP levels (48.2 +/- 2.8; p < 0.0005). During thyroid hormone therapy in euthyroid goiter, cAMP was significantly decreased (14.0 +/- 1.4; p < 0.05). 1 week after cessation of therapy a highly significant increase of cAMP was observed (38.2 +/- 6.9; p < 0.0005). There was a negative linear regression between T3 and cAMP (2p < 0.01). In pregnancy with hypertension cAMP was significantly elevated (30.5 +/- 3.8 p < 0.0005), but nearly normal under antihypertensive therapy. In pregnancy with edema only, no difference was found. Induction of labor with PGE2 alpha was followed by a decrease of plasma cAMP.
R Göser; K Jaschonek; D Kindler; E Keller; A E Schindler
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gynecologic and obstetric investigation     Volume:  11     ISSN:  0378-7346     ISO Abbreviation:  Gynecol. Obstet. Invest.     Publication Date:  1980  
Date Detail:
Created Date:  1981-03-24     Completed Date:  1981-03-24     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7900587     Medline TA:  Gynecol Obstet Invest     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  274-85     Citation Subset:  IM    
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MeSH Terms
Abortion, Threatened / blood
Cyclic AMP / blood*
Fenoterol / therapeutic use
Labor, Induced
Obstetric Labor, Premature / blood,  drug therapy
Pre-Eclampsia / blood
Pregnancy Complications / blood*
Prostaglandins F / therapeutic use
Thyroxine / pharmacology
Triiodothyronine / pharmacology
Reg. No./Substance:
0/Prostaglandins F; 13392-18-2/Fenoterol; 60-92-4/Cyclic AMP; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine

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