Document Detail

Plasma branched-chain amino acid levels and muscle energy metabolism in patients with chronic obstructive pulmonary disease.
MedLine Citation:
PMID:  19250720     Owner:  NLM     Status:  MEDLINE    
BACKGROUND & AIMS: Although several studies have shown that plasma concentrations of branched-chain amino acids (BCAAs) are reduced in patients with chronic obstructive pulmonary disease (COPD), little is understood about how low concentrations of BCAAs limit exercise in such patients. The present study investigated whether plasma BCAAs are related to energy metabolism in exercising muscle using (31)P-magnetic resonance spectroscopy (MRS). METHODS: We analyzed the plasma amino acid profiles of 23 male patients with COPD (aged 69.2+/-5.1 years) and of 7 healthy males (aged 64.1+/-6.0 years). We normalized the exercise intensity of repetitive lifting by adjusting the weight to 7% of the maximal grip power. The intracellular pH and the phosphocreatine (PCr) index (PCr/(PCr+Pi); Pi, inorganic phosphate) were calculated from MR spectra. We evaluated the relationship between intracellular pH and PCr index at the completion of exercise and the plasma BCAA concentration. RESULTS: Glutamine concentrations were elevated in patients with COPD compared with healthy individuals. Plasma concentrations of BCAAs correlated with intracellular pH and PCr index at the completion of exercise. CONCLUSIONS: The findings are consistent with the notion that BCAAs affect muscle energy metabolism during exercise in patients with COPD.
Tomoko Kutsuzawa; Sumie Shioya; Daisaku Kurita; Munetaka Haida
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-02-27
Journal Detail:
Title:  Clinical nutrition (Edinburgh, Scotland)     Volume:  28     ISSN:  1532-1983     ISO Abbreviation:  Clin Nutr     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-10     Completed Date:  2009-08-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309603     Medline TA:  Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  203-8     Citation Subset:  IM    
School of Health Sciences, Tokai University, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amino Acids, Branched-Chain / blood*
Energy Metabolism*
Glutamine / blood
Hydrogen-Ion Concentration
Magnetic Resonance Spectroscopy
Middle Aged
Muscle, Skeletal / metabolism*
Phosphocreatine / metabolism
Pulmonary Disease, Chronic Obstructive / blood,  metabolism*
Reg. No./Substance:
0/Amino Acids, Branched-Chain; 56-85-9/Glutamine; 67-07-2/Phosphocreatine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effect of zinc supplementation on the zinc level in serum and urine and their relation to thyroid ho...
Next Document:  Aspergillosis of the maxillary sinus secondary to a foreign body (amalgam) in the maxillary antrum.