| Plasma brain natriuretic peptide levels indicating thromboembolism in very elderly patients with non-valvular atrial fibrillation. | |
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MedLine Citation:
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PMID: 17721026 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Assessment of left atrial (LA) function by transesophageal echocardiography is useful for detecting patients with a high risk thromboembolism secondary to atrial fibrillation (AF). A recent study showed that the atrium is the main source of brain natriuretic peptide (BNP) in AF patients without overt heart failure. The purpose of this study was to assess the possible relationship between LA function and plasma BNP levels in very elderly patients with non-valvular AF. METHODS AND RESULTS: Seventy-four consecutive patients with chronic non-valvular AF (aged, 82+/-6 years) underwent transthoracic and transesophageal echocardiography and measurement of plasma BNP. Thirteen AF patients who had a history of cerebral embolism or echocardiographic evidence of thrombus (TE+ group) were compared with 61 AF patients who had no such complications (TE- group). The TE+ group demonstrated a lower LA appendage (LAA) velocity and higher plasma BNP level than the TE- group. Assessment of variables by multiple logistic regression analysis revealed that BNP was a significant predictor of thromboembolism. There was a significant negative correlation between the plasma BNP level and the LAA peak flow velocity. CONCLUSIONS: The present findings would suggest the usefulness of measuring plasma BNP to detect very elderly non-valvular AF patients at high risk for thromboembolism. |
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Authors:
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Daisuke Watanabe; Kazuhiko Shizuka; Shunichi Koyama; Toshihiko Iwamoto |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 71 ISSN: 1346-9843 ISO Abbreviation: Circ. J. Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-08-27 Completed Date: 2007-12-28 Revised Date: 2008-03-03 |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
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Languages: eng Pagination: 1446-51 Citation Subset: IM |
Affiliation:
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Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan. d_wata@tokyo-med.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Atrial Fibrillation / blood*, complications, therapy Echocardiography, Transesophageal Female Health Services for the Aged* Humans Intracranial Embolism / blood*, diagnosis, etiology, therapy Male Natriuretic Peptide, Brain / blood* Predictive Value of Tests Risk Factors |
| Chemical | |
Reg. No./Substance:
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114471-18-0/Natriuretic Peptide, Brain |
| Comments/Corrections | |
Comment In:
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Circ J. 2008 Jan;72(1):170; author reply 171
[PMID:
18159122
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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