Document Detail

Plasma and bone concentrations of cefuroxime and flucloxacillin. Oral versus parenteral administration in 20 arthroplasties.
MedLine Citation:
PMID:  8237317     Owner:  NLM     Status:  MEDLINE    
Our objective was to determine and to compare the range of bone levels of cefuroxime and flucloxacillin achieved after oral and intravenous administration in 20 arthroplasty patients, allocated to 4 groups: 1 x 500 mg or 7 x 500 mg oral cefuroxime was followed by 2000 mg Flucloxacillin i.v.; 1 x 500 mg and 7 x 500 mg oral flucloxacillin was followed by 1500 mg cefuroxime i.v. Bone samples of hip and knee were obtained. Oral administration did not result in a measurable bone concentration of any of the antibiotics. Intravenous administration resulted in measurable bone concentrations of both cefuroxime and flucloxacillin, with large inter-individual variations. The bone concentrations of intravenous cefuroxime were higher than those of flucloxacillin, despite the lower dose. Oral pretreatment had no effect on the bone concentrations after intravenous administration. No accumulation of the drugs in bone was observed.
M M Alvarez Ferrero; T B Vree; A M Baars; T J Slooff
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acta orthopaedica Scandinavica     Volume:  64     ISSN:  0001-6470     ISO Abbreviation:  Acta Orthop Scand     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1993-12-22     Completed Date:  1993-12-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370352     Medline TA:  Acta Orthop Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  525-9     Citation Subset:  IM    
Institute of Orthopedics, Academic Hospital Nijmegen Sint Radboud, The Netherlands.
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MeSH Terms
Administration, Oral
Aged, 80 and over
Bone and Bones / metabolism*
Cefuroxime / administration & dosage,  blood,  pharmacokinetics*
Floxacillin / administration & dosage,  blood,  pharmacokinetics*
Hip Prosthesis*
Infusions, Intravenous
Knee Prosthesis
Middle Aged
Prosthesis-Related Infections / prevention & control*
Reg. No./Substance:
5250-39-5/Floxacillin; 55268-75-2/Cefuroxime

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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