Document Detail


Plasma biomarker profiles in acute exacerbation of idiopathic pulmonary fibrosis.
MedLine Citation:
PMID:  20418386     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Little is known about the pathobiology of acute exacerbation of idiopathic pulmonary fibrosis (IPF), a condition that shares clinical and histopathological features with acute lung injury. Plasma biomarkers have been well studied in acute lung injury and have provided insight into the underlying disease mechanism. The objective of this study was to determine the plasma biomarker profile of acute exacerbation of IPF and compare this profile with that of stable IPF and acute lung injury. Plasma was collected from patients with stable IPF, acute exacerbation of IPF, and acute lung injury for measurement of biomarkers of cellular activity/injury (receptor for advanced glycation endproducts, surfactant protein D, KL-6, von Willebrand factor), systemic inflammation (IL-6), and coagulation/fibrinolysis (protein C, thrombomodulin, plasminogen activator inhibitor-1). Plasma from patients with acute exacerbation of IPF showed significant elevations in markers of type II alveolar epithelial cell injury and/or proliferation, endothelial cell injury, and coagulation. This profile differed from the biomarker profile in patients with acute lung injury. These findings support the hypothesis that type II alveolar epithelial cells are centrally involved in the pathobiology of acute exacerbation of IPF. Furthermore, they suggest that acute exacerbation of IPF has a distinct plasma biomarker profile from that of acute lung injury.
Authors:
Harold R Collard; Carolyn S Calfee; Paul J Wolters; Jin Woo Song; Sang-Bum Hong; Sandra Brady; Akitoshi Ishizaka; Kirk D Jones; Talmadge E King; Michael A Matthay; Dong Soon Kim
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-04-23
Journal Detail:
Title:  American journal of physiology. Lung cellular and molecular physiology     Volume:  299     ISSN:  1522-1504     ISO Abbreviation:  Am. J. Physiol. Lung Cell Mol. Physiol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-14     Completed Date:  2010-07-08     Revised Date:  2012-06-05    
Medline Journal Info:
Nlm Unique ID:  100901229     Medline TA:  Am J Physiol Lung Cell Mol Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  L3-7     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of California San Francisco, San Francisco, California, USA.
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MeSH Terms
Descriptor/Qualifier:
Acute Lung Injury / blood,  pathology,  physiopathology
Aged
Biological Markers / blood*
Humans
Idiopathic Pulmonary Fibrosis / blood*,  pathology,  physiopathology
Male
Middle Aged
Survival Rate
Grant Support
ID/Acronym/Agency:
HL-086516/HL/NHLBI NIH HHS; HL-090833/HL/NHLBI NIH HHS; HL-51854/HL/NHLBI NIH HHS; HL-51856/HL/NHLBI NIH HHS; K23 HL090833/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers
Comments/Corrections
Comment In:
Am J Physiol Lung Cell Mol Physiol. 2010 Jul;299(1):L1-2   [PMID:  20472711 ]

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