Document Detail

Plasma beta-endorphin concentrations and analgesia-muscle relaxation in the newborn infant supported by mechanical ventilation.
MedLine Citation:
PMID:  8021759     Owner:  NLM     Status:  MEDLINE    
We evaluated the effects of pancuronium and opiates on plasma beta-endorphin concentrations in 25 infants supported by mechanical ventilation. Infants receiving opiate were randomly assigned to receive either fentanyl or morphine. There was no change in beta-endorphin concentrations after administration of pancuronium, whereas both fentanyl and morphine reduced beta-endorphin concentrations by approximately 60%.
S P Ionides; M G Weiss; M Angelopoulos; T F Myers; R J Handa
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  125     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1994 Jul 
Date Detail:
Created Date:  1994-07-29     Completed Date:  1994-07-29     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  113-6     Citation Subset:  AIM; IM    
Department of Pediatrics and Cell Biology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois.
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MeSH Terms
Fentanyl / pharmacology,  therapeutic use*
Infant, Newborn
Morphine / pharmacology,  therapeutic use*
Muscle Relaxation / drug effects
Pancuronium / pharmacology,  therapeutic use*
Prospective Studies
Respiration, Artificial / adverse effects
Respiratory Tract Diseases / therapy
Stress, Physiological / blood,  drug therapy*,  etiology
beta-Endorphin / blood*
Reg. No./Substance:
0/Pancuronium; 437-38-7/Fentanyl; 57-27-2/Morphine; 60617-12-1/beta-Endorphin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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