| Plasma atrial natriuretic factor during chronic thoracic inferior vena caval constriction. | |
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MedLine Citation:
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PMID: 2962784 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of chronic constriction of the thoracic inferior vena cava (TIVCC) on plasma atrial natriuretic factor (pANF) were studied in conscious dogs (n = 5). TIVCC decreased left and right atrial pressure and led to a decrease in pANF concentration from 199 +/- 12 to 104 +/- 14 pg/ml while plasma renin and vasopressin concentrations increased. These hormonal changes were associated with a significant fall in sodium excretion to less than 5 meg/day. pANF remained suppressed during chronic TIVCC as the dogs expanded their extracellular fluid volume and developed ascites. Acute release of TIVCC resulted in abrupt increases in left and right atrial pressure but only a modest rise in pANF from 96 +/- 16 to 185 +/- 45 pg/ml. The magnitude of the rise in pANF (twofold) contrasted sharply with the eightfold increase in sodium excretion that occurred over the first 24 hours. Our data suggest that decrease in atrial pressure below normal results in a decline in pANF, which, acting in concert with the activated renin-angiotensin system and vasopressin, may contribute to sodium retention. On the other hand, during acute release of TIVCC, which markedly increased atrial pressure and sodium excretion, pANF only returned to control levels. These data suggest that ANF release may be attenuated during chronic reduction in atrial pressure and also raise a question concerning the magnitude of the primary role of ANF in this natriuretic response. |
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Authors:
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W C Paganelli; J R Cant; R R Pintal; I Kifor; A C Barger; V J Dzau |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Circulation research Volume: 62 ISSN: 0009-7330 ISO Abbreviation: Circ. Res. Publication Date: 1988 Feb |
Date Detail:
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Created Date: 1988-03-10 Completed Date: 1988-03-10 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0047103 Medline TA: Circ Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 279-85 Citation Subset: IM |
Affiliation:
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Department of Physiology, Harvard Medical School, Boston, MA 02115. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arginine Vasopressin / blood Atrial Natriuretic Factor / blood* Blood Pressure Dogs Male Renin / blood Sodium / metabolism Vasoconstriction* Vena Cava, Inferior / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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HL 36568/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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113-79-1/Arginine Vasopressin; 7440-23-5/Sodium; 85637-73-6/Atrial Natriuretic Factor; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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