| Plasma ascorbate concentrations and blood cell dehydroascorbate transport in patients with diabetes mellitus. | |
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MedLine Citation:
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PMID: 6708818 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rates of dehydroascorbate uptake by blood granulocytes and mononuclear cells are slower, and plasma ascorbate concentrations are lower, among persons with diabetes mellitus than in nondiabetic subjects. These measurements do not correlate with one another or with simultaneously measured plasma glucose or glycosylated hemoglobin; they do not differ with type of diabetes or mode of treatment. In those diabetic granulocytes that exhibit slow dehydroascorbate uptake, maximal velocity (Vmax) transport rates for dehydroascorbate, 2-deoxyglucose, and 3-O-methylglucose are decreased, each to the same degree, while Km values for transport of these ligands are not different from those observed in nondiabetic cells. Since diffusion of these ligands is facilitated by a common transporter, these observations may reflect decreased numbers of glucose transporters in the plasma membranes of some diabetic leukocytes. |
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Authors:
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L Stankova; M Riddle; J Larned; K Burry; D Menashe; J Hart; R Bigley |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Metabolism: clinical and experimental Volume: 33 ISSN: 0026-0495 ISO Abbreviation: Metab. Clin. Exp. Publication Date: 1984 Apr |
Date Detail:
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Created Date: 1984-05-04 Completed Date: 1984-05-04 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375267 Medline TA: Metabolism Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 347-53 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3-O-Methylglucose Adult Aged Ascorbic Acid / analogs & derivatives*, blood* Biological Transport Blood Cells / metabolism* Dehydroascorbic Acid / blood* Deoxyglucose / blood Diabetes Mellitus / blood* Female Granulocytes / metabolism Humans Leukocytes / metabolism Male Methylglucosides / blood Middle Aged Monocytes / metabolism Neutrophils / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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AM 27483/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Methylglucosides; 146-72-5/3-O-Methylglucose; 154-17-6/Deoxyglucose; 490-83-5/Dehydroascorbic Acid; 50-81-7/Ascorbic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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