Document Detail


Plasma apelin concentration is depressed following acute myocardial infarction in man.
MedLine Citation:
PMID:  19351633     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: Apelin, a novel peptide with a putative role in cardiovascular homeostasis, has gained interest as an endogenous inotrope, but has yet to be described following acute myocardial infarction (AMI) in man. We aimed to characterize plasma apelin concentrations following AMI and to examine its relationship with clinical and prognostic biomarkers.
METHODS AND RESULTS: Plasma concentrations of apelin, N-terminal probrain natriuretic peptide (NT-proBNP), norepinephrine, and arginine vasopressin were measured in 100 patients [mean age 58.9 +/- 12 (SD) years, 77% male] admitted with AMI, with echocardiographic left ventricular (LV) ejection fraction <40%, at mean 46 h after admission and at 24 weeks. Cardiac magnetic resonance imaging was performed pre-discharge and at 24 weeks. Thirty-eight subjects with no cardiac history acted as controls. Apelin concentration was reduced early after AMI (0.54 +/- 0.25 vs. 3.22 +/- 3.01 ng/mL, P <0.001) and remained low at 24 weeks, although it did increase significantly from baseline to 0.62 +/- 0.36 ng/mL, P = 0.030. Apelin had no relationship with any parameter of LV function over time. A relationship was found between baseline apelin and norepinephrine (r = 0.26, P = 0.008). Both NT-proBNP and norepinephrine correlated with adverse ventricular function after AMI.
CONCLUSION: Plasma apelin concentration is reduced early after AMI, increases significantly over time, but remains depressed at 24 weeks.
Authors:
Robin A P Weir; Kwok Shiong Chong; Jonathan R Dalzell; Colin J Petrie; Charles A Murphy; Tracey Steedman; Patrick B Mark; Theresa A McDonagh; Henry J Dargie; John J V McMurray
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2009-04-06
Journal Detail:
Title:  European journal of heart failure     Volume:  11     ISSN:  1388-9842     ISO Abbreviation:  Eur. J. Heart Fail.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-26     Completed Date:  2009-09-01     Revised Date:  2013-11-25    
Medline Journal Info:
Nlm Unique ID:  100887595     Medline TA:  Eur J Heart Fail     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  551-8     Citation Subset:  IM    
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00132093
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MeSH Terms
Descriptor/Qualifier:
Biological Markers / blood
Chromatography, High Pressure Liquid
Double-Blind Method
Echocardiography
Female
Follow-Up Studies
Heart Ventricles / pathology,  physiopathology,  ultrasonography
Humans
Intercellular Signaling Peptides and Proteins / blood*
Ligands
Magnetic Resonance Imaging
Male
Middle Aged
Mineralocorticoid Receptor Antagonists / therapeutic use
Myocardial Infarction / blood*,  drug therapy,  physiopathology
Prognosis
Spironolactone / analogs & derivatives,  therapeutic use
Stroke Volume
Ventricular Dysfunction, Left / blood,  etiology,  prevention & control
Ventricular Remodeling / physiology*
Chemical
Reg. No./Substance:
0/APLN protein, human; 0/Biological Markers; 0/Intercellular Signaling Peptides and Proteins; 0/Ligands; 0/Mineralocorticoid Receptor Antagonists; 27O7W4T232/Spironolactone; 6995V82D0B/eplerenone

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