| Plasma aminoacid levels across the brain in patients with respiratory failure. | |
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MedLine Citation:
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PMID: 6409628 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Animal studies and theoretical considerations have suggested that in hypercapnic respiratory failure there is interconversion of glutamic acid to glutamine within the brain, perhaps as part of a local buffering mechanism to minimize hypercapnia-induced cerebral acidosis. Detection of transcerebral arteriovenous differences, positive for glutamic acid and negative for glutamine, would lend support to this hypothesis. We measured arterial and internal jugular venous levels of twenty-three aminoacids in four patients with hypercapnic respiratory failure and in four suitable controls. In patients, arterial as well as venous glutamine levels were elevated proportionally, and there was no demonstrable A-V difference across the brain; arterial and venous glutamic acid levels were the same as controls. All other aminoacid levels, arterial and venous, were normal. These findings confirm the previous observations that in hypercapnic respiratory failure glutamine metabolism is altered, but provide no support for the proposed glutamic acid-glutamine interconversions within the brain. |
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Authors:
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C Cangiano; M O Farber; P Cardelli-Cangiano; L R Roberts; J H James; A Cascino; E M Cockerill; F Manfredi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of clinical investigation Volume: 13 ISSN: 0014-2972 ISO Abbreviation: Eur. J. Clin. Invest. Publication Date: 1983 Feb |
Date Detail:
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Created Date: 1983-09-20 Completed Date: 1983-09-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0245331 Medline TA: Eur J Clin Invest Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 87-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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blood* Brain / blood supply* Cerebral Arteries Glutamates / blood Glutamine / blood Humans Hypercapnia / blood, complications Jugular Veins Respiratory Insufficiency / blood*, etiology |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Glutamates; 56-85-9/Glutamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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