Document Detail

Plasma aminoacid levels across the brain in patients with respiratory failure.
MedLine Citation:
PMID:  6409628     Owner:  NLM     Status:  MEDLINE    
Animal studies and theoretical considerations have suggested that in hypercapnic respiratory failure there is interconversion of glutamic acid to glutamine within the brain, perhaps as part of a local buffering mechanism to minimize hypercapnia-induced cerebral acidosis. Detection of transcerebral arteriovenous differences, positive for glutamic acid and negative for glutamine, would lend support to this hypothesis. We measured arterial and internal jugular venous levels of twenty-three aminoacids in four patients with hypercapnic respiratory failure and in four suitable controls. In patients, arterial as well as venous glutamine levels were elevated proportionally, and there was no demonstrable A-V difference across the brain; arterial and venous glutamic acid levels were the same as controls. All other aminoacid levels, arterial and venous, were normal. These findings confirm the previous observations that in hypercapnic respiratory failure glutamine metabolism is altered, but provide no support for the proposed glutamic acid-glutamine interconversions within the brain.
C Cangiano; M O Farber; P Cardelli-Cangiano; L R Roberts; J H James; A Cascino; E M Cockerill; F Manfredi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of clinical investigation     Volume:  13     ISSN:  0014-2972     ISO Abbreviation:  Eur. J. Clin. Invest.     Publication Date:  1983 Feb 
Date Detail:
Created Date:  1983-09-20     Completed Date:  1983-09-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0245331     Medline TA:  Eur J Clin Invest     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  87-9     Citation Subset:  IM    
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MeSH Terms
Amino Acids / blood*
Brain / blood supply*
Cerebral Arteries
Glutamates / blood
Glutamine / blood
Hypercapnia / blood,  complications
Jugular Veins
Respiratory Insufficiency / blood*,  etiology
Reg. No./Substance:
0/Amino Acids; 0/Glutamates; 56-85-9/Glutamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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