Document Detail

Plasma amino-terminal pro C-type natriuretic Peptide in the neonate: relation to gestational age and postnatal linear growth.
MedLine Citation:
PMID:  17971429     Owner:  NLM     Status:  MEDLINE    
CONTEXT: C-type natriuretic peptide (CNP) plays an essential role in endochondral bone growth. Insight into CNP's paracrine actions is possible using plasma measurements of the amino-terminal pro C-type natriuretic peptide (NTproCNP). Whether correlations of NTproCNP with linear growth, as found in children and lambs, apply in neonates is unknown. OBJECTIVES: Our objective was to determine the effects of prematurity, gender, and antenatal steroids on plasma NTproCNP at birth, and serial changes in hormone concentrations, linear growth, and markers of bone turnover in the first month of postnatal life. DESIGN AND SETTING: This is a prospective study of newborn infants admitted to an intensive care unit. SUBJECTS: A total of 48 infants (four gestation groups) were enrolled. Umbilical cord samples were also obtained from 39 healthy term infants. MAIN OUTCOME MEASURES: Plasma NTproCNP and CNP were measured in cord plasma. In enrolled neonates, serial measurements of hormone concentrations and markers of bone turnover were related to tibial growth velocity as measured by knemometry. RESULTS: Cord plasma NTproCNP was inversely related to gestational age (r = -0.35; P = 0.003) and was higher in males (P < 0.001). Plasma NTproCNP (P = 0.016) and CNP (P < 0.001) increased within the first week of life, the increase relating inversely to gestational age (r = -0.64; P < 0.001). Plasma NTproCNP at 1 wk was strongly correlated with linear growth velocity (r = 0.49; P < 0.001), and also at 2-4 wk, the relation being stronger than observed between bone turnover markers and growth velocity. CONCLUSIONS: In neonates with diverse disorders affecting growth and nutrition, plasma NTproCNP was strongly correlated with linear growth during the first 4 wk of postnatal life and may prove to be a novel marker of growth plate activity in neonates.
Timothy C R Prickett; Bronwyn Dixon; Chris Frampton; Timothy G Yandle; A Mark Richards; Eric A Espiner; Brian A Darlow
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-10-30
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  93     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-07     Completed Date:  2008-03-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  225-32     Citation Subset:  AIM; IM    
Department of Medicine, Christchurch School of Medicine and Health Sciences, PO Box 4345, Christchurch Mail Centre, Christchurch 8140, New Zealand.
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MeSH Terms
Betamethasone / pharmacology
Birth Weight
Child Development / physiology*
Cohort Studies
Collagen Type I / blood
Fetal Blood / metabolism
Gestational Age
Glucocorticoids / pharmacology
Infant, Newborn
Infant, Premature / blood*,  growth & development*
Leg / physiology
Natriuretic Peptide, C-Type / blood*
Peptide Fragments / blood
Peptides / blood
Procollagen / blood
Prospective Studies
Statistics, Nonparametric
Reg. No./Substance:
0/Collagen Type I; 0/Glucocorticoids; 0/Peptide Fragments; 0/Peptides; 0/Procollagen; 0/collagen type I trimeric cross-linked peptide; 0/procollagen Type I N-terminal peptide; 127869-51-6/Natriuretic Peptide, C-Type; 378-44-9/Betamethasone

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