| Plasma adiponectin levels are related to obesity, inflammation, blood lipids and insulin in type 2 diabetic and non-diabetic Trinidadians. | |
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MedLine Citation:
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PMID: 20580627 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To determine the relationship between plasma adiponectin levels and obesity, inflammation, blood lipids and insulin resistance in type 2 diabetics (T2DM) and non-diabetics in a patient population in Trinidad. METHODS: A cohort study of a total of 126 type 2 diabetic (42 males and 84 females) and 140 (43 males and 97 females) non-diabetic public clinic attendees were assessed between December 2008 and July 2009. Along with clinical history and anthropometry, adiponectin, TNF-α, IL-6, CRP, lipid profile, glucose, and insulin were measured in fasting blood samples and insulin resistance (HOMA-IR) was calculated. RESULTS: Diabetics had higher (p<0.05) glucose, insulin, HOMA-IR, triglycerides (TG), VLDL and systolic blood pressure than non-diabetics, but lower (p<0.05) HDL and adiponectin levels. Adiponectin levels were lower (p<0.05) in obese than in non-obese individuals regardless of diabetic status. There were significant gender differences in HDL, LDL and TG. Among non-obese persons, adiponectin correlated negatively with triglycerides (r=-0.280; adiponectin), IL-6 (r=-0.216; p<0.005), HOMA-IR (r=-0.373; p=000) and positively correlated with HDL (r=0.355; p=0.000). Diabetic status (p=0.025), TNF-α (p=0.048) and BMI (p=0.027) were identified as useful predictors of adiponectin by multiple linear regression methods. In addition binary logistic regression analysis found glucose (p=0.001) and adiponectin (p=0.047) to be useful indicators of type 2 diabetes. CONCLUSIONS: Adiponectin decreases with increasing adiposity and insulin resistance. Adiponectin and TNF-α appear to be related to differences in the insulin mediated glucose turnover. |
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Authors:
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B Shivananda Nayak; Deepak Ramsingh; Shanaree Gooding; George Legall; Sanjiv Bissram; Atif Mohammed; Anupama Raychaudhuri; Brad Sahadeo; Varoon Pandohie; Kemron Figaro |
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Publication Detail:
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Type: Journal Article Date: 2010-06-30 |
Journal Detail:
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Title: Primary care diabetes Volume: 4 ISSN: 1751-9918 ISO Abbreviation: Prim Care Diabetes Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-27 Completed Date: 2011-01-20 Revised Date: 2012-04-09 |
Medline Journal Info:
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Nlm Unique ID: 101463825 Medline TA: Prim Care Diabetes Country: England |
Other Details:
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Languages: eng Pagination: 187-92 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Faculty of Medical Sciences, The University of the West Indies, St Augustine, Trinidad and Tobago. shivananda.nayak@sta.uwi.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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blood Adiposity / ethnology Adult Biological Markers / blood Blood Pressure C-Reactive Protein / analysis Case-Control Studies Diabetes Mellitus, Type 2 / blood*, ethnology, immunology, physiopathology Female Humans Inflammation / blood*, ethnology, immunology, physiopathology Inflammation Mediators / blood Insulin / blood* Insulin Resistance / ethnology Interleukin-6 Linear Models Lipids / blood* Logistic Models Male Middle Aged Obesity / blood*, ethnology, immunology, physiopathology Risk Assessment Risk Factors Trinidad and Tobago Tumor Necrosis Factor-alpha / blood |
| Chemical | |
Reg. No./Substance:
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0/ADIPOQ protein, human; 0/Adiponectin; 0/Biological Markers; 0/IL6 protein, human; 0/Inflammation Mediators; 0/Insulin; 0/Interleukin-6; 0/Lipids; 0/Tumor Necrosis Factor-alpha; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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