| Plasma adiponectin concentration in early pregnancy and subsequent risk of hypertensive disorders. | |
| | |
MedLine Citation:
|
PMID: 16055585 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Adiponectin is an exclusively adipose tissue-derived protein. Low plasma adiponectin levels have been found in hypertensive men. Our objective was to evaluate whether low first-trimester plasma adiponectin values were predictive of hypertensive disorders later in pregnancy. METHODS: A nested case-control study was carried out on a cohort of 1,842 pregnant women who participated in the first-trimester Down syndrome screening program; 34 developed preeclampsia and 48 gestational hypertension. A control group of 82 nonhypertensive uneventful pregnancies was selected. Plasma adiponectin was determined using an enzyme-linked immunosorbent assay (ELISA). RESULTS: Adiponectin median concentrations in the group which subsequently became hypertensive were significantly lower than those in the control group (7.6 versus 13.0 microg/mL) (P < .001). When the 2 hypertensive subgroups were considered, the plasma adiponectin median value in the preeclampsia group was significantly lower than that in the gestational hypertension group (6.6 versus 9.3 microg/mL) (P = .01). Regression analysis showed an inverse correlation between plasma adiponectin concentrations and maternal age, gestational age, body mass index, systolic blood pressure, and proteinuria. Approximately 34% of hypertensive pregnancies, compared with 7% of controls (P < .001), had plasma adiponectin concentrations less than 6.4 microg/mL (mean value of lower quartile of distribution among control patients). After adjusting for maternal age, all these women experienced a 6.6-fold (95% confidence interval 2.5-17.8) increased risk of pregnancy hypertension, compared with those women who had higher concentrations. CONCLUSION: Our findings suggest a strong association between hypoadiponectinemia and the risk of hypertensive disorders in pregnancy, especially with preeclampsia. |
| | |
Authors:
|
Rosario D'Anna; Giovanni Baviera; Francesco Corrado; Domenico Giordano; Antonino Di Benedetto; Valerio M Jasonni |
Related Documents
:
|
8894325 - Hemodynamic profiles in severe preeclamptic and superimposed preeclamptic pregnancies. 20308605 - Increased sensitivity to angiotensin ii is present postpartum in women with a history o... 9580915 - Prescription of activity restriction to treat high-risk pregnancies. 17320785 - Why african-american women are at greater risk for pregnancy-related death. 8098075 - Ectopic pregnancy and occupational exposure to antineoplastic drugs. 17318015 - Euthyroid women with autoimmune disease undergoing assisted reproduction technologies: ... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Obstetrics and gynecology Volume: 106 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 2005 Aug |
Date Detail:
|
Created Date: 2005-08-01 Completed Date: 2005-09-02 Revised Date: 2009-10-26 |
Medline Journal Info:
|
Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: United States |
Other Details:
|
Languages: eng Pagination: 340-4 Citation Subset: AIM; IM |
Affiliation:
|
Department of Obstetrics and Gynecology, University of Messina, Messina, Italy. rosariodanna@tin.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adiponectin Adult Case-Control Studies Enzyme-Linked Immunosorbent Assay Female Humans Hypertension, Pregnancy-Induced / etiology* Intercellular Signaling Peptides and Proteins / blood* Pre-Eclampsia / etiology* Pregnancy Pregnancy Trimester, First |
| Chemical | |
Reg. No./Substance:
|
0/Adiponectin; 0/Intercellular Signaling Peptides and Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Maternal hypertension and neonatal outcome among small for gestational age infants.
Next Document: Increased low-density lipoprotein susceptibility to oxidation in pregnancies and fetal growth restri...