Document Detail


Plasma adiponectin concentration is associated with ambulatory daytime systolic blood pressure but not with the dipping status.
MedLine Citation:
PMID:  20010617     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of this study was to analyse the relationship between the ambulatory blood pressure (ABP) measurement and plasma adiponectin levels in a population-based cohort. Non-hypertensive, non-diabetics from the Oulu Project Elucidating Risk of Atherosclerosis cohort aged 40-60 years with ABP measurement available in 226 men and 236 women were analysed. ABP was recorded using the fully automatic SpaceLabs 90207 oscillometric unit. Plasma adiponectin concentrations were assayed using the enzyme-linked immunosorbent assay method. Without adjustment the highest plasma adiponectin tertile was associated with the lowest ABP and office BP measurements (P from 0.025 to P<0.001, respectively). Only the association of plasma adiponectin concentration with systolic ABP was independent of other conventional risk factors (age, body mass index (BMI), waist, gender, insulin sensitivity index, smoking and alcohol consumption) for hypertension (P=0.017). No association was observed between systolic dipping pattern and adiponectin level. The plasma high adiponectin concentration is independently associated with low daytime systolic ABP value. The mechanisms may include effects on endothelial function and the sympathetic nervous system.
Authors:
R L Vasunta; Y A Kesäniemi; O Ukkola
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-12-10
Journal Detail:
Title:  Journal of human hypertension     Volume:  24     ISSN:  1476-5527     ISO Abbreviation:  J Hum Hypertens     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-15     Completed Date:  2010-10-22     Revised Date:  2012-04-09    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  545-51     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland.
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MeSH Terms
Descriptor/Qualifier:
Adiponectin / blood
Adult
Blood Pressure / physiology*
Blood Pressure Monitoring, Ambulatory
Case-Control Studies
Circadian Rhythm / physiology*
Cohort Studies
Female
Humans
Hypertension / diagnosis,  epidemiology*,  metabolism*
Male
Middle Aged
Risk Factors
Sex Distribution
Sympathetic Nervous System / physiology
Chemical
Reg. No./Substance:
0/ADIPOQ protein, human; 0/Adiponectin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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