| Plasma adiponectin concentration is associated with ambulatory daytime systolic blood pressure but not with the dipping status. | |
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MedLine Citation:
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PMID: 20010617 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this study was to analyse the relationship between the ambulatory blood pressure (ABP) measurement and plasma adiponectin levels in a population-based cohort. Non-hypertensive, non-diabetics from the Oulu Project Elucidating Risk of Atherosclerosis cohort aged 40-60 years with ABP measurement available in 226 men and 236 women were analysed. ABP was recorded using the fully automatic SpaceLabs 90207 oscillometric unit. Plasma adiponectin concentrations were assayed using the enzyme-linked immunosorbent assay method. Without adjustment the highest plasma adiponectin tertile was associated with the lowest ABP and office BP measurements (P from 0.025 to P<0.001, respectively). Only the association of plasma adiponectin concentration with systolic ABP was independent of other conventional risk factors (age, body mass index (BMI), waist, gender, insulin sensitivity index, smoking and alcohol consumption) for hypertension (P=0.017). No association was observed between systolic dipping pattern and adiponectin level. The plasma high adiponectin concentration is independently associated with low daytime systolic ABP value. The mechanisms may include effects on endothelial function and the sympathetic nervous system. |
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Authors:
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R L Vasunta; Y A Kesäniemi; O Ukkola |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-12-10 |
Journal Detail:
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Title: Journal of human hypertension Volume: 24 ISSN: 1476-5527 ISO Abbreviation: J Hum Hypertens Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-15 Completed Date: 2010-10-22 Revised Date: 2012-04-09 |
Medline Journal Info:
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Nlm Unique ID: 8811625 Medline TA: J Hum Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 545-51 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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blood Adult Blood Pressure / physiology* Blood Pressure Monitoring, Ambulatory Case-Control Studies Circadian Rhythm / physiology* Cohort Studies Female Humans Hypertension / diagnosis, epidemiology*, metabolism* Male Middle Aged Risk Factors Sex Distribution Sympathetic Nervous System / physiology |
| Chemical | |
Reg. No./Substance:
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0/ADIPOQ protein, human; 0/Adiponectin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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