Document Detail


Plasma adenosine deaminase isoform 2 in cancer patients undergoing chemotherapy.
MedLine Citation:
PMID:  22558798     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Adenosine deaminase (AD), a purine salvage enzyme, exists as AD isoform 1 (AD1) and AD isoform 2 (AD2). Plasma AD has been advocated for the screening and monitoring of cancer, as AD2 activity is increased in conditions associated with tumour growth. Plasma AD2 was measured before and seven to 10 days after the first dose of chemotherapy in patients with different tumours. A 'tumour regression score' was assessed independently based on radiological changes seen in the tumour following completion of chemotherapy. Changes in plasma AD2 were then compared with the tumour regression score. Following first-dose chemotherapy, plasma AD2 decreased on average from 22.7 +/- 10.5 U/L to 15.0 +/- 4.6 U/L. The percentage decrease in plasma AD2 correlated with the tumour regression score (r=0.5, P=0.028). These data suggest plasma AD2 may have a role in determining tumour response to treatment.
Authors:
E L Roberts; O T Roberts
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of biomedical science     Volume:  69     ISSN:  0967-4845     ISO Abbreviation:  Br. J. Biomed. Sci.     Publication Date:  2012  
Date Detail:
Created Date:  2012-05-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9309208     Medline TA:  Br J Biomed Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  11-3     Citation Subset:  IM    
Affiliation:
Clinical Biochemistry, Bronglais General Hospital, Aberystwyth SY23 1ER, UK. elton.roberts07@btinternet.com
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