Document Detail


Plasma adenosine concentration increases during exercise: a possible contributing factor in exercise-induced bronchoconstriction in asthma.
MedLine Citation:
PMID:  11897989     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated whether the level of plasma adenosine (ADO) changed during exercise and whether this could be related to exercise-induced bronchoconstriction. Baseline levels of ADO did not differ, but exercise resulted in higher ADO in patients with asthma than in healthy subjects (86 +/- 35 vs 59 +/- 16 nmol/L; P <.001). In patients with asthma, the increase in ADO was related to decreases in FEV(1) (r (2) = 0.475; P <.05) and SaO(2) (r (2) = 0.693; P <.05). These data suggest that adenosine might be involved in the development of exercise-induced bronchoconstriction.
Authors:
Eva Vizi; Eva Huszár; Zsuzsa Csoma; György Böszörményi-Nagy; Erzsébet Barát; Ildikó Horváth; Irén Herjavecz; Márk Kollai
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  109     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-18     Completed Date:  2002-04-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  446-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Pathophysiology, National Korányi Institute for Tuberculosis and Pulmonology, Budapest, Hungary.
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MeSH Terms
Descriptor/Qualifier:
Adenosine / blood*
Adolescent
Adult
Asthma, Exercise-Induced / blood,  etiology*,  physiopathology
Bronchoconstriction*
Female
Forced Expiratory Volume
Humans
Male
Physical Exertion*
Chemical
Reg. No./Substance:
58-61-7/Adenosine
Comments/Corrections
Comment In:
J Allergy Clin Immunol. 2002 Sep;110(3):537; author reply 537-8   [PMID:  12209113 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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