Document Detail

Plasma YKL-40 is elevated in patients with recurrent atrial fibrillation after catheter ablation.
MedLine Citation:
PMID:  20012147     Owner:  NLM     Status:  MEDLINE    
AIM: To study plasma YKL-40 in patients with atrial fibrillation (AF) treated with radiofrequency (RF) catheter ablation and to assess the predictive role of plasma YKL-40 and its changes after restoration of sinus rhythm (SR). METHODS: Forty-six patients (mean age 55 years, range 31-81) with paroxysmal/persistent AF were treated with RF catheter ablation; Holter monitoring for 14 days was performed before ablation and after 3 months. Recurrent symptomatic AF or atrial tachycardia >10 min was considered failure, and the patients were offered a second ablation session. YKL-40 was determined in plasma samples taken prior to ablation and at follow-up visits up to 12 months after ablation. RESULTS: After a maximum of two ablations, 19 patients (41%) had SR without recurrence of AF after 12 months. The patients with no recurrence of AF had significantly lower baseline plasma levels of YKL-40 prior to ablation compared to patients with recurrence of AF (31 vs. 62 microg/l, P = 0.029). Plasma YKL-40 was not an independent predictor of recurrence of AF after ablation. No significant changes in plasma YKL-40 levels were seen from baseline to follow-up at 12 months. CONCLUSION: In patients with paroxysmal or persistent AF treated with catheter ablation, high plasma YKL-40 before ablation is associated with recurrence of AF.
Kristoffer Mads Henningsen; Brian Nilsson; Julia S Johansen; Xu Chen; Steen Pehrson; Jesper Hastrup Svendsen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-12-10
Journal Detail:
Title:  Inflammation research : official journal of the European Histamine Research Society ... [et al.]     Volume:  59     ISSN:  1420-908X     ISO Abbreviation:  Inflamm. Res.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-13     Completed Date:  2010-08-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508160     Medline TA:  Inflamm Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  463-9     Citation Subset:  IM    
Department of Cardiology, Cardiac Catheterization Laboratory 2014, The Heart Centre, Rigshospitalet, University of Copenhagen, 2100 Copenhagen Ø, Denmark.
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MeSH Terms
Aged, 80 and over
Atrial Fibrillation / blood*,  surgery*
Biological Markers
Catheter Ablation*
Electrocardiography, Ambulatory
Enzyme-Linked Immunosorbent Assay
Follow-Up Studies
Glycoproteins / blood*
Lectins / blood*
Logistic Models
Middle Aged
Treatment Outcome
Reg. No./Substance:
0/Biological Markers; 0/CHI3L1 protein, human; 0/Glycoproteins; 0/Lectins

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