| Plasma Vaspin Concentrations Are Elevated in Metabolic Syndrome in Men and Are Correlated with Coronary Atherosclerosis in Women. | |
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MedLine Citation:
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PMID: 21545478 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: Vaspin is visceral adipose-tissue-derived adipokine, which has an insulin-sensitizing effect in obese type 2 diabetic rodent models. Since adipokines may serve as a link between visceral adiposity and atherosclerosis, we investigated whether plasma vaspin concentrations were associated with the metabolic syndrome and coronary atherosclerosis. Design and Methods: We measured fasting plasma vaspin levels in 81 subjects with the metabolic syndrome and 241 age- and sex-matched control subjects without the metabolic syndrome using the enzyme-linked immunosorbent assay. Multi-detector row cardiac computed tomography was performed to evaluate coronary atherosclerosis. We analyzed sex specific plasma vaspin concentrations according to the presence of the metabolic syndrome and the severity of coronary atherosclerosis. Results: Plasma vaspin concentrations were significantly higher in men with the metabolic syndrome compared to those without the metabolic syndrome (median 0.60 [inter-quartile range 0.40-0.99] ng/ml vs. 0.40 [0.26-0.66] ng/ml, P = 0.002). There was a positive correlation between plasma vaspin concentrations and body mass index, waist circumference, and percent body fat in men. However, these relationships were not found in women. Plasma vaspin concentrations were associated with presence and severity of coronary artery stenosis such as, higher Agatstone calcium score, number of diseased vessels and characteristics of coronary artery plaque only in women. Conclusions: Higher plasma vaspin concentrations are significantly associated with metabolic syndrome in men. In women, vaspin concentrations are associated with coronary atherosclerosis. Further studies regarding the role of vaspin in the pathogenesis of obesity and atherosclerosis are required. |
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Authors:
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Sung Hee Choi; Soo Heon Kwak; Yenna Lee; Min Kyung Moon; Soo Lim; Young Joo Park; Hak C Jang; Min Seon Kim |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-4 |
Journal Detail:
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Title: Clinical endocrinology Volume: - ISSN: 1365-2265 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0346653 Medline TA: Clin Endocrinol (Oxf) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Blackwell Publishing Ltd. |
Affiliation:
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Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea Seoul National University Bundang Hospital, Gyeonggi-do, Korea Seoul National University Boramae Hospital, Seoul, Korea Department of Internal Medicine, University of Ulsan College of Medicine, Seoul, Korea. |
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