Document Detail


Plasma and urine dimercaptopropanesulfonate concentrations after dermal application of transdermal DMPS (TD-DMPS).
MedLine Citation:
PMID:  23143832     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
2,3-Dimercaptopropane-1-sulfonate (DMPS) is a metal chelator approved in Europe for oral or intravenous use for heavy metal poisoning. Transdermally applied DMPS (TD-DMPS) is used by some alternative practitioners to treat autism, despite the absence of evidence for its efficacy. We found no literature evaluating the pharmacokinetics of the transdermal route of delivery or the ability of TD-DMPS to enhance urinary mercury elimination. We hypothesized that TD-DMPS is not absorbed. Eight adult volunteers underwent application of 1.5-3 drops/kg of TD-DMPS. Subjects provided 12-h urine collections the day before and day of application. Subjects underwent blood draws at 0, 30, 60,90, 120, and 240 min after TD-DMPS application. Plasma and urine were assayed for the presence of DMPS. Urine was assayed for any change in urinary mercury excretion after DMPS. One control subject ingested 250 mg of oral DMPS and underwent the same urine and blood collections and analyses. No subject had detectable urine DMPS or increased urine mercury excretion after TD-DMPS. One subject had detectable levels of DMPS in the 30-min plasma sample, suspected to be contamination. All other samples for that subject and the other seven subjects showed no detectable plasma DMPS. The control subject had detectable urine and plasma DMPS levels and increased urine mercury excretion. These results indicate that TD-DMPS is not absorbed. There was no increase in urine mercury excretion after TD-DMPS. Our results argue that TD-DMPS is an ineffective metal chelator.
Authors:
Jennifer P Cohen; Anne-Michelle Ruha; Steven C Curry; Kallol Biswas; Benjamin Westenberger; Wei Ye; Kathleen L Caldwell; Frank Lovecchio; Keith Burkhart; Nasr Samia
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of medical toxicology : official journal of the American College of Medical Toxicology     Volume:  9     ISSN:  1937-6995     ISO Abbreviation:  J Med Toxicol     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-20     Completed Date:  2013-08-06     Revised Date:  2014-03-07    
Medline Journal Info:
Nlm Unique ID:  101284598     Medline TA:  J Med Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  9-15     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Administration, Oral
Adult
Chelating Agents / administration & dosage,  pharmacokinetics*
Female
Humans
Male
Mercury Compounds / urine
Middle Aged
Unithiol / administration & dosage,  pharmacokinetics*
Chemical
Reg. No./Substance:
0/Chelating Agents; 0/Mercury Compounds; 4076-02-2/Unithiol
Comments/Corrections
Comment In:
J Med Toxicol. 2013 Mar;9(1):1-3   [PMID:  23224992 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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