Document Detail


Plasma S100B level after acute spontaneous intracerebral hemorrhage.
MedLine Citation:
PMID:  17008613     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: We sought to determine plasma S100B level after acute (<24 hours) spontaneous intracerebral hemorrhage (ICH) and to study its relation with neurological outcome. METHODS: We determined S100B concentration on plasma samples from 78 ICH patients on admission. Clinical (Glasgow Coma Scale and National Institutes of Health Stroke Scale [NIHSS] scores) and radiological information (ICH and perihematomal edema volumes) were collected at baseline and follow-up visits. Early neurological deterioration, defined as the increase of >or=4 points in the NIHSS score at 48 hours, and unfavorable outcome (modified Rankin Scale >2) at 3 months were also recorded. RESULTS: The median S100B level was higher than our laboratory reference values for healthy controls (103.6 versus 48.5 pg/mL; P<0.001) and a positive correlation was observed between S100B level and baseline ICH volume (r=0.45; P<0.0001). The median S100B level was higher in patients who deteriorated early (256.8 versus 89.7 pg/mL; P=0.001) and also in patients with an unfavorable outcome (136 versus 75.9 pg/mL; P=0.003). Multivariate analysis showed baseline ICH volume as the best predictor for both early neurological deterioration (odds ratio 15; 95% CI, 2.9 to 76.3) and unfavorable outcome at 3 months (odds ratio 17; 95% CI, 2.0 to 142). CONCLUSIONS: Increased S100B level is found after acute spontaneous ICH, in association with a worse early and late evolution, and closely related to initial hematoma volume.
Authors:
Pilar Delgado; Jose Alvarez Sabin; Esteban Santamarina; Carlos A Molina; Manuel Quintana; Anna Rosell; Joan Montaner
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2006-09-28
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  37     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-31     Completed Date:  2006-11-14     Revised Date:  2007-03-20    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2837-9     Citation Subset:  IM    
Affiliation:
Neurovascular Research Laboratory, Stroke Unit, Departament de Medicina, Universitat Autònoma de Barcelona, Hospital General Vall d'Hebron, Barcelona, Spain. 35070pdm@comb.es
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Aged
Aged, 80 and over
Cerebral Hemorrhage / blood*,  physiopathology
Female
Hematoma / blood
Humans
Male
Middle Aged
Nerve Growth Factors / blood*
S100 Proteins / blood*
Time Factors
Chemical
Reg. No./Substance:
0/Nerve Growth Factors; 0/S-100 calcium-binding protein beta subunit; 0/S100 Proteins
Comments/Corrections
Erratum In:
Stroke. 2007 Mar;38(3):1117

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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