| Plasma S100B level after acute spontaneous intracerebral hemorrhage. | |
MedLine Citation:
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PMID: 17008613 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: We sought to determine plasma S100B level after acute (<24 hours) spontaneous intracerebral hemorrhage (ICH) and to study its relation with neurological outcome. METHODS: We determined S100B concentration on plasma samples from 78 ICH patients on admission. Clinical (Glasgow Coma Scale and National Institutes of Health Stroke Scale [NIHSS] scores) and radiological information (ICH and perihematomal edema volumes) were collected at baseline and follow-up visits. Early neurological deterioration, defined as the increase of >or=4 points in the NIHSS score at 48 hours, and unfavorable outcome (modified Rankin Scale >2) at 3 months were also recorded. RESULTS: The median S100B level was higher than our laboratory reference values for healthy controls (103.6 versus 48.5 pg/mL; P<0.001) and a positive correlation was observed between S100B level and baseline ICH volume (r=0.45; P<0.0001). The median S100B level was higher in patients who deteriorated early (256.8 versus 89.7 pg/mL; P=0.001) and also in patients with an unfavorable outcome (136 versus 75.9 pg/mL; P=0.003). Multivariate analysis showed baseline ICH volume as the best predictor for both early neurological deterioration (odds ratio 15; 95% CI, 2.9 to 76.3) and unfavorable outcome at 3 months (odds ratio 17; 95% CI, 2.0 to 142). CONCLUSIONS: Increased S100B level is found after acute spontaneous ICH, in association with a worse early and late evolution, and closely related to initial hematoma volume. |
Authors:
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Pilar Delgado; Jose Alvarez Sabin; Esteban Santamarina; Carlos A Molina; Manuel Quintana; Anna Rosell; Joan Montaner |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2006-09-28 |
Journal Detail:
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Title: Stroke; a journal of cerebral circulation Volume: 37 ISSN: 1524-4628 ISO Abbreviation: Stroke Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-10-31 Completed Date: 2006-11-14 Revised Date: 2007-03-20 |
Medline Journal Info:
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Nlm Unique ID: 0235266 Medline TA: Stroke Country: United States |
Other Details:
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Languages: eng Pagination: 2837-9 Citation Subset: IM |
Affiliation:
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Neurovascular Research Laboratory, Stroke Unit, Departament de Medicina, Universitat Autònoma de Barcelona, Hospital General Vall d'Hebron, Barcelona, Spain. 35070pdm@comb.es |
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Aged Aged, 80 and over Cerebral Hemorrhage / blood*, physiopathology Female Hematoma / blood Humans Male Middle Aged Nerve Growth Factors / blood* S100 Proteins / blood* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Nerve Growth Factors; 0/S-100 calcium-binding protein beta subunit; 0/S100 Proteins |
| Comments/Corrections | |
Erratum In:
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Stroke. 2007 Mar;38(3):1117 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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