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Plasma Platelet-derived Microparticles in Patients with Connective Tissue Diseases.
MedLine Citation:
PMID:  21239749     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To clarify the role of platelet-derived microparticles (PDMP), which are small vesicles with thrombotic and immunological properties, in systemic lupus erythematosus (SLE), systemic sclerosis (SSc), dermatomyositis/polymyositis (PM/DM), and mixed connective tissue disease (MCTD). METHODS: Plasma levels of PDMP were measured by ELISA, and compared among patients with one of the 4 diseases. Association of PDMP levels with clinical characteristics and medication of the patients was also examined. RESULTS: PDMP levels were higher in patients with MCTD and SSc than in controls. Multiple linear regression analysis revealed that patients with Raynaud's phenomenon (RP) showed higher PDMP levels than those without. PDMP levels in individual patients did not fluctuate significantly over several months. CONCLUSION: PDMP level is associated with MCTD, SSc, and RP, and could be a novel marker for RP.
Authors:
Chinami Oyabu; Akio Morinobu; Daisuke Sugiyama; Jun Saegusa; Shino Tanaka; Sahoko Morinobu; Goh Tsuji; Shimpei Kasagi; Seiji Kawano; Shunichi Kumagai
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-15
Journal Detail:
Title:  The Journal of rheumatology     Volume:  -     ISSN:  0315-162X     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
From the Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Kobe, Japan. C. Oyabu, Graduate Student, Department of Clinical Laboratory, Kobe University Hospital, Department of Clinical Pathology and Immunology; A. Morinobu, MD, Associate Professor, Department of Clinical Pathology and Immunology; D. Sugiyama, MD, Assistant Professor; J. Saegusa, MD, Assistant Professor; S. Tanaka, BS, Technician, Department of Evidence-Based Laboratory Medicine; S. Morinobu, MD, Staff Clinician; G. Tsuji, MD, Assistant Professor; S. Kasagi, MD, Assistant Professor, Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine; S. Kawano, MD, Lecturer, Department of Clinical Laboratory, Kobe University Hospital, Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine; S. Kumagai, MD, Professor, Department of Clinical Pathology and Immunology, Department of Evidence-Based Laboratory Medicine, Kobe University Graduate School of Medicine.
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