| Plasma phospholipid transfer protein deficiency in mice is associated with a reduced thrombotic response to acute intravascular oxidative stress. | |
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MedLine Citation:
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PMID: 20864671 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Earlier in vitro studies suggested a putative role for the plasma phospholipid transfer protein (PLTP) in the modulation of blood coagulation. The effect of PLTP expression on blood coagulation under both basal and oxidative stress conditions was compared here in wild-type and PLTP-deficient (PLTP-/-) mice. METHODS AND RESULTS: Under basal conditions, PLTP deficiency was associated with an extended tail bleeding time despite a significant depletion of vascular α-tocopherol content and an impairment of endothelial function. When acute oxidative stress was generated in vivo in the brain vasculature, the steady state levels of oxidized lipid derivatives, the extent of blood vessel occlusion, and the volume of ischemic lesions were more severe in wild-type than in PLTP-/- mice. CONCLUSIONS: In addition to its recognized hyperlipidemic, proinflammatory, and proatherogenic properties, PLTP increases blood coagulation and worsens the extent of ischemic lesions in response to acute oxidative stress. Thus, PLTP arises here as a cardiovascular risk factor for the late thrombotic events occurring in the acute phase of atherosclerosis. |
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Authors:
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Catherine Desrumaux; Valérie Deckert; Stéphanie Lemaire-Ewing; Claude Mossiat; Anne Athias; David Vandroux; Laure Dumont; Serge Monier; Jean-Paul Pais de Barros; Alexis Klein; Emmanuel De Maistre; Denis Blache; Alain Beley; Christine Marie; Philippe Garnier; Laurent Lagrost |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-23 |
Journal Detail:
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Title: Arteriosclerosis, thrombosis, and vascular biology Volume: 30 ISSN: 1524-4636 ISO Abbreviation: Arterioscler. Thromb. Vasc. Biol. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-18 Completed Date: 2010-12-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9505803 Medline TA: Arterioscler Thromb Vasc Biol Country: United States |
Other Details:
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Languages: eng Pagination: 2452-7 Citation Subset: IM |
Affiliation:
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Institut National de la Santé et de la Recherche Médicale, UMR866, Dijon, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bleeding Time Blood Coagulation* Cerebral Infarction / blood, genetics, pathology, physiopathology, prevention & control* Dose-Response Relationship, Drug Endothelium, Vascular / drug effects, metabolism*, physiopathology Intracranial Thrombosis / blood, genetics, pathology, physiopathology, prevention & control* Linoleic Acids / metabolism Lipid Metabolism Mice Mice, Inbred C57BL Mice, Knockout Oxidation-Reduction Oxidative Stress* Phospholipid Transfer Proteins / deficiency*, genetics Vasodilator Agents / pharmacology alpha-Tocopherol / blood |
| Chemical | |
Reg. No./Substance:
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0/Linoleic Acids; 0/Phospholipid Transfer Proteins; 0/Vasodilator Agents; 0/phospholipid transfer protein, mouse; 59-02-9/alpha-Tocopherol |
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