| Plasma phospholipid fatty acid concentration and incident coronary heart disease in men and women: the EPIC-Norfolk prospective study. | |
| | |
MedLine Citation:
|
PMID: 22802735 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The lack of association found in several cohort studies between dietary saturated fat and coronary heart disease (CHD) risk has renewed debate over the link between dietary fats and CHD. METHODS AND FINDINGS: We assessed the relationship between plasma phospholipid fatty acid (PFA) concentration and incident CHD using a nested case control design within a prospective study (EPIC-Norfolk) of 25,639 individuals aged 40-79 years examined in 1993-1997 and followed up to 2009. Plasma PFA concentrations were measured by gas chromatography in baseline samples retrieved from frozen storage. In 2,424 men and women with incident CHD compared with 4,930 controls alive and free of cardiovascular disease, mean follow-up 13 years, saturated PFA (14:0, 16:0,18:0) plasma concentrations were significantly associated with increased CHD risk (odds ratio [OR] 1.75, 95% CI 1.27-2.41, p<0.0001), in top compared to bottom quartiles (Q), and omega-6 polyunsaturated PFA concentrations were inversely related (OR 0.77, 0.60-0.99, p<0.05) after adjusting for age, sex, body mass index, blood pressure, smoking, alcohol intake, plasma vitamin C, social class, education, and other PFAs. Monounsaturated PFA, omega-3 PFA, and trans PFA concentrations were not significantly associated with CHD. Odd chain PFA (15:0, 17:0) concentrations were significantly inversely associated with CHD (OR 0.73, 0.59-0.91, p<0.001, Q4 versus Q1). Within families of saturated PFA or polyunsaturated PFA, significantly heterogeneous relationships with CHD were observed for individual fatty acids. CONCLUSIONS: In this study, plasma concentrations of even chain saturated PFA were found to be positively and omega-6 polyunsaturated PFA inversely related to subsequent coronary heart disease risk. These findings are consistent with accumulating evidence suggesting a protective role of omega-6 fats substituting for saturated fats for CHD prevention. |
| | |
Authors:
|
Kay-Tee Khaw; Marlin D Friesen; Elio Riboli; Robert Luben; Nicholas Wareham |
Related Documents
:
|
18163395 - Understanding ethnic disparities in the use of total joint arthroplasty: application of... 19095095 - The recent decline in mammography rates is limited to low- to average-risk women. 11919065 - Early adult characteristics and mortality among inner-city african american women. 20354125 - Longitudinal predictors of nonadherence to maintenance of mammography. 10535785 - Periconceptional nutrient intake and risk for neural tube defect-affected pregnancies. 22869405 - Validation and refinement of a prediction rule to identify children at low risk for acu... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-07-03 |
Journal Detail:
|
Title: PLoS medicine Volume: 9 ISSN: 1549-1676 ISO Abbreviation: PLoS Med. Publication Date: 2012 |
Date Detail:
|
Created Date: 2012-07-17 Completed Date: 2012-11-16 Revised Date: 2013-04-01 |
Medline Journal Info:
|
Nlm Unique ID: 101231360 Medline TA: PLoS Med Country: United States |
Other Details:
|
Languages: eng Pagination: e1001255 Citation Subset: IM |
Affiliation:
|
Department of Public Health and Primary Care, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom. kk101@medschl.cam.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Case-Control Studies Coronary Disease / blood*, epidemiology* Fatty Acids / blood* Female Great Britain / epidemiology Humans Incidence Male Middle Aged Odds Ratio Phospholipids / blood* Prospective Studies |
| Grant Support | |
ID/Acronym/Agency:
|
//Cancer Research UK; //Medical Research Council |
| Chemical | |
Reg. No./Substance:
|
0/Fatty Acids; 0/Phospholipids |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: HIV treatment as prevention: modelling the cost of antiretroviral treatment--state of the art and fu...
Next Document: Risk factors for death among children less than 5 years old hospitalized with diarrhea in rural west...