Document Detail


Plasma phospholipid concentration of cis-palmitoleic acid and risk of heart failure.
MedLine Citation:
PMID:  23065037     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Although plasma palmitoleic acid has been positively associated with blood pressure, inflammation, and insulin resistance, its association with heart failure has not been investigated. We assessed whether plasma phospholipid cis-palmitoleic acid was associated with heart failure risk.
METHODS AND RESULTS: This ancillary study of the Physicians' Health Study used a risk set sampling method to select 788 matched pairs. For each case of incident heart failure, we randomly selected a control among subjects that were free of heart failure and alive at the time of index case diagnosis and matched on age, year of birth, race, and time of blood collection. Plasma phospholipid fatty acids were measured using gas chromatography. Heart failure was ascertained using annual follow-up questionnaire and validated in a subsample. In a multivariable conditional logistic regression, odds ratios (95% CI) for heart failure were 1.0 (ref), 1.06 (0.75-1.48), 1.20 (0.85-1.68), and 1.58 (1.11-2.25) across consecutive quartiles of cis-palmitoleic acid (P for trend 0.009). Each SD increase in plasma cis-palmitoleic acid was associated with 17% higher odds of heart failure (95% CI: 2% to 33%) in a multivariable model. In a secondary analysis, each SD increase of log-stearoyl-coA desaturase activity (16:1n-7/16:0 ratio) was positively associated with the risk of heart failure (odds ratio: 1.14 [95% CI: 1.00 to 1.29]), whereas oleic acid and cis-vaccenic acid concentrations were not related to heart failure risk.
CONCLUSIONS: Our data showed a positive association between plasma phospholipid cis- palmitoleic acid and heart failure risk in male physicians.
Authors:
Luc Djoussé; Natalie L Weir; Naomi Q Hanson; Michael Y Tsai; J Michael Gaziano
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-10-11
Journal Detail:
Title:  Circulation. Heart failure     Volume:  5     ISSN:  1941-3297     ISO Abbreviation:  Circ Heart Fail     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-21     Completed Date:  2013-04-01     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  101479941     Medline TA:  Circ Heart Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  703-9     Citation Subset:  IM    
Affiliation:
Division of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02120, USA. ldjousse@rics.bwh.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Biological Markers / blood
Case-Control Studies
Fatty Acids, Monounsaturated / blood*
Heart Failure / blood*,  epidemiology*
Humans
Logistic Models
Male
Middle Aged
Phospholipids / blood*
Physicians
Questionnaires
Risk Factors
United States
Grant Support
ID/Acronym/Agency:
CA-097193/CA/NCI NIH HHS; CA-34944/CA/NCI NIH HHS; CA-40360/CA/NCI NIH HHS; HL-26490/HL/NHLBI NIH HHS; HL-34595/HL/NHLBI NIH HHS; HL092946S/HL/NHLBI NIH HHS; R01 CA034944-03/CA/NCI NIH HHS; R01 CA040360/CA/NCI NIH HHS; R01 CA097193/CA/NCI NIH HHS; R01 HL026490-03/HL/NHLBI NIH HHS; R01 HL034595-07/HL/NHLBI NIH HHS; R01 HL092946/HL/NHLBI NIH HHS; R01HL092946/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Fatty Acids, Monounsaturated; 0/Phospholipids; 209B6YPZ4I/palmitoleic acid
Comments/Corrections

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