Document Detail


Plasma NEFA storage in adipose tissue in the postprandial state: sex-related and regional differences.
MedLine Citation:
PMID:  18712345     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS/HYPOTHESIS: We recently reported that a small fraction of circulating NEFA is stored through direct uptake in subcutaneous fat in postabsorptive humans in vivo and that this pathway may favour lower-body fat distribution in women. Here, we examined sex-related and regional differences in storage of plasma NEFA in subcutaneous adipose tissue during postprandial conditions.
METHODS: At 1 h after lunch, men and women of normal weight received an intravenous bolus of approximately 1.66 MBq [1-(14)C]oleate followed by timed subcutaneous fat biopsies. The preceding breakfast was either a normal- or high-fat meal; the high-fat breakfast was used to create postprandial oleate concentrations in the postabsorptive range.
RESULTS: Storage of the NEFA tracer in adipose tissue (dpm/g lipid) was greater in women; in both sexes abdominal fat stored tracer more avidly than femoral fat. A greater fraction of the administered tracer was stored in whole body subcutaneous fat of women than in that of men (27 +/- 3 vs 8 +/- 1%, respectively, p < 0.0001). No significant differences in tracer storage were observed between participants consuming the high- vs normal-fat breakfast.
CONCLUSIONS/INTERPRETATION: Postprandial NEFA storage in subcutaneous fat through direct uptake accounts for approximately 25% of NEFA disposal in women, but for <10% in men in a wide range of circulating NEFA concentrations. It is greater in the upper- than lower-body subcutaneous fat, favouring upper-body fat accumulation in both sexes.
Authors:
C Koutsari; C L H Snozek; M D Jensen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-08-19
Journal Detail:
Title:  Diabetologia     Volume:  51     ISSN:  0012-186X     ISO Abbreviation:  Diabetologia     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-07     Completed Date:  2008-11-18     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  0006777     Medline TA:  Diabetologia     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  2041-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / metabolism*
Adult
Blood Glucose / metabolism
Energy Intake
Fatty Acids, Nonesterified / blood,  metabolism*
Female
Humans
Insulin / blood
Lipoproteins, VLDL / metabolism
Male
Postprandial Period*
Premenopause
Reference Values
Sex Characteristics
Grant Support
ID/Acronym/Agency:
DK40484/DK/NIDDK NIH HHS; DK45343/DK/NIDDK NIH HHS; DK50456/DK/NIDDK NIH HHS; M01 RR000585/RR/NCRR NIH HHS; M01 RR000585-343105/RR/NCRR NIH HHS; P30 DK050456/DK/NIDDK NIH HHS; P30 DK050456-119004/DK/NIDDK NIH HHS; R01 DK045343/DK/NIDDK NIH HHS; R01 DK045343-17/DK/NIDDK NIH HHS; R37 DK040484/DK/NIDDK NIH HHS; R37 DK040484-21/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Insulin; 0/Lipoproteins, VLDL
Comments/Corrections

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