Document Detail


Plasma N-terminal atrial natriuretic peptide in acute myocardial infarction.
MedLine Citation:
PMID:  8197967     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Plasma atrial natriuretic peptide (ANP) and the N-terminal (NT) fragment of the 126-amino acid prohormone of ANP (proANP; NT-proANP) were correlated with clinical findings in 41 patients with acute myocardial infarction and in 19 patients with angina pectoris. On admission to the hospital, the 39 patients with nonfatal infarction who subsequently had overt heart failure (n = 8) had plasma NT-proANP (2374 +/- 1038 pmol/L) and ANP (54 +/- 43 pmol/L) concentrations that were higher (p < 0.01) than those in the patients who remained without or who presented with minor signs of failure. In contrast to the relatively stable NT-proANP levels, ANP decreased markedly during the first 24 hours in the patients who had any signs of failure. Hence the plasma levels of NT-proANP and ANP did not go hand in hand in acute myocardial infarction, and NT-proANP appeared to be a better marker of cardiac dysfunction than ANP.
Authors:
R V Kettunen; J Leppäluoto; A Jounela; O Vuolteenaho
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American heart journal     Volume:  127     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-06-29     Completed Date:  1994-06-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1449-55     Citation Subset:  AIM; IM    
Affiliation:
Department of Internal Medicine, University of Oulu, Finland.
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MeSH Terms
Descriptor/Qualifier:
Aged
Analysis of Variance
Angina Pectoris / blood,  drug therapy,  epidemiology
Atrial Natriuretic Factor / blood*,  drug effects
Female
Humans
Male
Middle Aged
Myocardial Infarction / blood*,  drug therapy,  epidemiology
Protein Precursors / blood*,  drug effects
Radioimmunoassay / methods,  statistics & numerical data
Streptokinase / therapeutic use
Thrombolytic Therapy
Chemical
Reg. No./Substance:
0/Protein Precursors; 85637-73-6/Atrial Natriuretic Factor; EC 3.4.-/Streptokinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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