| Plasma methionine sulfoxide in persons with familial Alzheimer's disease mutations. | |
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MedLine Citation:
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PMID: 22584618 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Convergent evidence suggests that oxidative stress plays a central role in the pathology of Alzheimer's disease (AD). We asked if consequently, oxidation of methionine residues to methionine sulfoxide (MetO) was increased in plasma proteins of persons carrying familial AD (FAD) mutations. METHODS: Plasma was collected from 31 persons from families harboring PSEN1 or APP mutations. Using Western blot analysis with a novel anti-MetO polyclonal antibody, MetO levels were measured and compared between FAD mutation carriers (MCs) and non-mutation carrying (NCs) kin. RESULTS: A MetO-positive 120-kDa gel band distinguished FAD MCs and NCs (mean 11.4 ± 2.8 vs. 4.0 ± 3.1, p = 0.02). In a subset of subjects for whom both measurements were available, MetO levels correlated well with plasma F2-isoprostane (r = 0.81, p < 0.001) and superoxide dismutase 1 (r = 0.52, p = 0.004) levels. CONCLUSION: Our data provide evidence for elevated MetO levels in persons carrying FAD mutations that correlate with other indices of oxidative stress and suggest that plasma oxidative stress markers may be useful for diagnosis of AD. |
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Authors:
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John M Ringman; Andrew T Fithian; Karen Gylys; Jeffrey L Cummings; Giovanni Coppola; David Elashoff; Domenico Pratico; Jackob Moskovitz; Gal Bitan |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-05-14 |
Journal Detail:
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Title: Dementia and geriatric cognitive disorders Volume: 33 ISSN: 1421-9824 ISO Abbreviation: Dement Geriatr Cogn Disord Publication Date: 2012 |
Date Detail:
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Created Date: 2012-07-20 Completed Date: 2012-11-29 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 9705200 Medline TA: Dement Geriatr Cogn Disord Country: Switzerland |
Other Details:
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Languages: eng Pagination: 219-25 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 S. Karger AG, Basel. |
Affiliation:
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Mary S. Easton Center for Alzheimer's Disease Research, Department of Neurology, University of California at Los Angeles, Los Angeles, CA 90095-7334, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alzheimer Disease / blood*, genetics* Amyloid beta-Protein Precursor / genetics Analysis of Variance Apolipoproteins E / genetics Blood Proteins / genetics Blotting, Western DNA / genetics Female Genotype Humans Isoprostanes / blood Male Methionine / analogs & derivatives*, blood Mutation / genetics, physiology Oxidative Stress / physiology Presenilin-1 / genetics Superoxide Dismutase / genetics |
| Grant Support | |
ID/Acronym/Agency:
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K08 AG-22228/AG/NIA NIH HHS; K08 AG022228/AG/NIA NIH HHS; M01 RR000865/RR/NCRR NIH HHS; M01-RR00865/RR/NCRR NIH HHS; P50 AG-16570/AG/NIA NIH HHS; P50 AG016570/AG/NIA NIH HHS; UL1 TR000124/TR/NCATS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amyloid beta-Protein Precursor; 0/Apolipoproteins E; 0/Blood Proteins; 0/Isoprostanes; 0/PSEN1 protein, human; 0/Presenilin-1; 454-41-1/methionine sulfoxide; 63-68-3/Methionine; 9007-49-2/DNA; EC 1.15.1.-/superoxide dismutase 1; EC 1.15.1.1/Superoxide Dismutase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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