| Plasma MR-proADM correlates to BMI and decreases in relation to leptin after gastric bypass surgery. | |
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MedLine Citation:
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PMID: 19247278 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Adrenomedullin (ADM) is a vasoactive peptide found to be related to obesity and its comorbidities: type 2 diabetes, hypertension, atherosclerosis, and coronary heart disease. ADM is increased both in plasma and in adipose tissue of obese individuals when compared to lean subjects and is considered as a member of the adipokine family. We determined plasma midregional proadrenomedullin (MR-proADM) concentrations in a cohort of 357 subjects with BMI ranging from 17.5 to 42.3 kg/m2 and no additional medical history. In parallel, 28 severely obese patients scheduled to undergo laparoscopic Roux-en-Y gastric bypass (RYGB) surgery were studied at two time points: before and 1 year after surgery. Outcome measurements were: MR-proADM, cortisol, leptin, C-reactive protein (CRP) thyroid-stimulating hormone (TSH), creatinine and metabolic parameters. BMI correlated significantly to plasma MR-proADM levels (r=0.714, P<0.001), also after adjustment for age and gender (r=0.767, P<0.001). In obese subjects, there was a positive relationship between MR-proADM and leptin (r=0.511, P=0.006). Following RYGB, plasma MR-proADM decreased from 0.76+/-0.03 to 0.62+/-0.02 pg/ml (P<0.0001). RYGB-induced changes in MR-proADM correlated significantly to changes in leptin (r=0.533, P=0.004) and in CRP (r=0.429, P=0.023). We conclude that BMI is an independent predictor of circulating MR-proADM levels. Weight loss after RYGB is associated with a significant decrease in plasma MR-proADM, which is related to surgery-induced changes in both circulating leptin and systemic inflammation. |
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Authors:
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Greisa Vila; Michaela Riedl; Christina Maier; Joachim Struck; Nils G Morgenthaler; Ammon Handisurya; Gerhard Prager; Bernhard Ludvik; Martin Clodi; Anton Luger |
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Publication Detail:
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Type: Journal Article Date: 2009-02-26 |
Journal Detail:
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Title: Obesity (Silver Spring, Md.) Volume: 17 ISSN: 1930-7381 ISO Abbreviation: Obesity (Silver Spring) Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-07-08 Completed Date: 2009-07-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101264860 Medline TA: Obesity (Silver Spring) Country: United States |
Other Details:
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Languages: eng Pagination: 1184-8 Citation Subset: IM |
Affiliation:
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Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria. greisa.vila@meduniwien.ac.at |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenomedullin
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blood* Biological Markers Body Mass Index* Cross-Sectional Studies Down-Regulation Female Gastric Bypass* Humans Inflammation Mediators / blood Leptin / blood* Male Obesity / blood, physiopathology, surgery* Protein Precursors / blood* Severity of Illness Index Time Factors Treatment Outcome Weight Loss* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Inflammation Mediators; 0/Leptin; 0/Protein Precursors; 0/proadrenomedullin; 148498-78-6/Adrenomedullin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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