| Plasma MHPG in depression: effects of acute and chronic desipramine treatment. | |
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MedLine Citation:
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PMID: 6945615 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of acute and chronic desmethylimipramine (DMI) administration on 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG) in plasma and urine were examined in eight depressed inpatients. DMI treatment induced an immediate and continuous highly significant reduction in plasma MHPG throughout the 30-day treatment period. This effect was not related to treatment response. In contrast to plasma MHPG, there was no uniform effect of DMI treatment on urinary MHPG. Chronic DMI treatment increased or did not change urinary MHPG in the three treatment responders and decreased urinary MHPG in five nonresponders. The correlation between plasma and urinary MHPG during the placebo period was not significant, and the effect of DMI treatment on the two measures differed markedly. |
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Authors:
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D S Charney; G R Heninger; D E Sternberg; R H Roth |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Psychiatry research Volume: 5 ISSN: 0165-1781 ISO Abbreviation: Psychiatry Res Publication Date: 1981 Oct |
Date Detail:
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Created Date: 1981-12-21 Completed Date: 1981-12-21 Revised Date: 2008-04-17 |
Medline Journal Info:
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Nlm Unique ID: 7911385 Medline TA: Psychiatry Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 217-29 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Depressive Disorder / blood*, drug therapy Desipramine / therapeutic use* Female Glycols / blood* Humans Locus Coeruleus / drug effects Male Methoxyhydroxyphenylglycol / blood*, urine Middle Aged Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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MH-14,276/MH/NIMH NIH HHS; MH-25,642/MH/NIMH NIH HHS; MH-30,929/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Glycols; 50-47-5/Desipramine; 534-82-7/Methoxyhydroxyphenylglycol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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