Document Detail


Plasma MHPG in depression: effects of acute and chronic desipramine treatment.
MedLine Citation:
PMID:  6945615     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of acute and chronic desmethylimipramine (DMI) administration on 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG) in plasma and urine were examined in eight depressed inpatients. DMI treatment induced an immediate and continuous highly significant reduction in plasma MHPG throughout the 30-day treatment period. This effect was not related to treatment response. In contrast to plasma MHPG, there was no uniform effect of DMI treatment on urinary MHPG. Chronic DMI treatment increased or did not change urinary MHPG in the three treatment responders and decreased urinary MHPG in five nonresponders. The correlation between plasma and urinary MHPG during the placebo period was not significant, and the effect of DMI treatment on the two measures differed markedly.
Authors:
D S Charney; G R Heninger; D E Sternberg; R H Roth
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Psychiatry research     Volume:  5     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  1981 Oct 
Date Detail:
Created Date:  1981-12-21     Completed Date:  1981-12-21     Revised Date:  2008-04-17    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  217-29     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Depressive Disorder / blood*,  drug therapy
Desipramine / therapeutic use*
Female
Glycols / blood*
Humans
Locus Coeruleus / drug effects
Male
Methoxyhydroxyphenylglycol / blood*,  urine
Middle Aged
Time Factors
Grant Support
ID/Acronym/Agency:
MH-14,276/MH/NIMH NIH HHS; MH-25,642/MH/NIMH NIH HHS; MH-30,929/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Glycols; 50-47-5/Desipramine; 534-82-7/Methoxyhydroxyphenylglycol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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