| Plasma lipid metabolites are associated with gestational age but not bronchopulmonary dysplasia. | |
| | |
MedLine Citation:
|
PMID: 22497282 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIM: To test the hypothesis that plasma lipid metabolite levels in premature infants are associated with the development of bronchopulmonary dysplasia (BPD). The studies also tested a secondary hypothesis that plasma lipid metabolite levels were correlated with gestational age. METHODS: Infants born <32 weeks' gestation were enrolled during the first 72 h of life. Plasma samples were obtained and lipid levels were measured by LC-MS/MS. Clinical data were collected to determine infant outcomes and BPD diagnosis. RESULTS: Following adjustment for confounders, lipid levels were not associated with BPD; however, levels of specific lipid metabolites were correlated with gestational age. CONCLUSION: Immature lipid metabolism pathways in premature infants may contribute to the pathogenesis of BPD and other diseases. |
| | |
Authors:
|
Lynette K Rogers; Christine M Young; Michael L Pennell; Trent E Tipple; Karen L Leonhart; Stephen E Welty |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-05-02 |
Journal Detail:
|
Title: Acta paediatrica (Oslo, Norway : 1992) Volume: 101 ISSN: 1651-2227 ISO Abbreviation: Acta Paediatr. Publication Date: 2012 Aug |
Date Detail:
|
Created Date: 2012-07-13 Completed Date: 2012-11-05 Revised Date: 2013-05-16 |
Medline Journal Info:
|
Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: Norway |
Other Details:
|
Languages: eng Pagination: e321-6 Citation Subset: IM |
Copyright Information:
|
© 2012 The Author(s)/Acta Paediatrica © 2012 Foundation Acta Paediatrica. |
Affiliation:
|
Department of Pediatrics, Center for Perinatal Research, The Research Institute at Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA. lynette.rogers@nationwidechildrens.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Bronchopulmonary Dysplasia
/
blood* Chromatography, Liquid Fatty Acids, Unsaturated / blood* Female Gestational Age* Humans Infant, Newborn Infant, Premature Linear Models Logistic Models Male Prospective Studies Tandem Mass Spectrometry |
| Grant Support | |
ID/Acronym/Agency:
|
K08 HL093365/HL/NHLBI NIH HHS; R01 AT006880/AT/NCCAM NIH HHS; UL1 TR000090/TR/NCATS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Fatty Acids, Unsaturated |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The N-terminal domain of a TonB-dependent transporter undergoes a reversible stepwise denaturation.
Next Document: Classification of the geographical origin of Italian donkey's milk based on differences in inorganic...