Document Detail


Plasma lipid metabolites are associated with gestational age but not bronchopulmonary dysplasia.
MedLine Citation:
PMID:  22497282     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To test the hypothesis that plasma lipid metabolite levels in premature infants are associated with the development of bronchopulmonary dysplasia (BPD). The studies also tested a secondary hypothesis that plasma lipid metabolite levels were correlated with gestational age.
METHODS: Infants born <32 weeks' gestation were enrolled during the first 72 h of life. Plasma samples were obtained and lipid levels were measured by LC-MS/MS. Clinical data were collected to determine infant outcomes and BPD diagnosis.
RESULTS: Following adjustment for confounders, lipid levels were not associated with BPD; however, levels of specific lipid metabolites were correlated with gestational age.
CONCLUSION: Immature lipid metabolism pathways in premature infants may contribute to the pathogenesis of BPD and other diseases.
Authors:
Lynette K Rogers; Christine M Young; Michael L Pennell; Trent E Tipple; Karen L Leonhart; Stephen E Welty
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-05-02
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  101     ISSN:  1651-2227     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-13     Completed Date:  2012-11-05     Revised Date:  2013-07-02    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  e321-6     Citation Subset:  IM    
Copyright Information:
© 2012 The Author(s)/Acta Paediatrica © 2012 Foundation Acta Paediatrica.
Affiliation:
Department of Pediatrics, Center for Perinatal Research, The Research Institute at Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA. lynette.rogers@nationwidechildrens.org
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MeSH Terms
Descriptor/Qualifier:
Bronchopulmonary Dysplasia / blood*
Chromatography, Liquid
Fatty Acids, Unsaturated / blood*
Female
Gestational Age*
Humans
Infant, Newborn
Infant, Premature
Linear Models
Logistic Models
Male
Prospective Studies
Tandem Mass Spectrometry
Grant Support
ID/Acronym/Agency:
K08 HL093365/HL/NHLBI NIH HHS; R01 AT006880/AT/NCCAM NIH HHS; UL1 TR000090/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids, Unsaturated
Comments/Corrections

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