Document Detail


Plasma levels of FABP4, but not FABP3, are associated with increased risk of diabetes.
MedLine Citation:
PMID:  22706792     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Little is known about the association between plasma concentrations of fatty acid binding protein 3 and 4 and the risk of diabetes in population-based cohorts. In a prospective nested case-control design, we studied 149 cases of diabetes and 149 matched controls from the Physicians' Health Study. Plasma fatty acid binding proteins were measured on frozen specimens collected between 1995 and 2001 by ELISA. Cases of diabetes were self-reported and validated in a subsample via review of medical records. We used conditional logistic regression to estimate multivariable relative risks. The mean age at baseline was 64.9 years and median plasma fatty acid binding protein 3 and 4 were 2.12 ng/ml (IQR 1.62-2.66) and 15.32 ng/ml (IQR 12.14-18.73), respectively. In separate models, each fatty acid binding protein was positively associated with the risk of diabetes in a conditional logistic regression adjusting for matching variables, smoking, and hypertension. However, upon adjustment for each other, only fatty acid binding protein 4 (but not 3) was positively associated with the risk of diabetes [relative risk (95 % CI) 1.0 (reference), 2.73 (1.08-6.89), 2.66 (1.11-6.42), and 6.89 (2.83-16.80) across consecutive quartiles of fatty acid binding protein 4, P for trend <0.0001]. The FABP4-diabetes association was modified by body mass index (P interaction 0.03). Our data showed a positive association between plasma fatty acid binding protein 4 but not 3 and the risk of diabetes in US male physicians. The interaction with body mass index warrants further investigations.
Authors:
Luc Djoussé; J Michael Gaziano
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-06-16
Journal Detail:
Title:  Lipids     Volume:  47     ISSN:  1558-9307     ISO Abbreviation:  Lipids     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-25     Completed Date:  2012-12-11     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  757-62     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Body Mass Index
Case-Control Studies
Diabetes Mellitus, Type 2 / epidemiology*,  etiology
Fatty Acid-Binding Proteins / blood*
Humans
Logistic Models
Male
Middle Aged
Prospective Studies
Risk
Risk Factors
United States / epidemiology
Grant Support
ID/Acronym/Agency:
CA-097193/CA/NCI NIH HHS; CA-34944/CA/NCI NIH HHS; CA-40360/CA/NCI NIH HHS; HL-26490/HL/NHLBI NIH HHS; HL-34595/HL/NHLBI NIH HHS; R01 CA034944/CA/NCI NIH HHS; R01 CA034944-03/CA/NCI NIH HHS; R01 CA040360/CA/NCI NIH HHS; R01 CA097193/CA/NCI NIH HHS; R01 HL026490/HL/NHLBI NIH HHS; R01 HL026490-03/HL/NHLBI NIH HHS; R01 HL034595/HL/NHLBI NIH HHS; R01 HL034595-07/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/FABP3 protein, human; 0/FABP4 protein, human; 0/Fatty Acid-Binding Proteins
Comments/Corrections

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