| Plasma level of platelet-derived microparticles is associated with coronary heart disease risk score in healthy men. | |
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MedLine Citation:
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PMID: 20379056 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: The aim of this study was to clarify the relationship between platelet-derived microparticles (PDMPs) and the Framingham 10-yr coronary heart disease (CHD) risk score. METHODS: A cross-sectional study of healthy volunteers free of medication, and cardiovascular or cerebrovascular disease was conducted. The subjects were 190 Japanese men (median age 41). An ELISA kit and monoclonal antibodies against CD42b and CD42a (glycoprotein Ib and IX) were used. RESULTS: PDMPs are correlated with platelet count, high sensitivity C-reactive protein (hsCRP), and diastolic blood pressure by multivariate analysis (R(2)=0.316, p <0.001). Quartile range of PDMPs is significantly associated with the 10-yr CHD risk score after adjusting for age, platelet count, hsCRP, and hypertension (p=0.033) and for age, platelet count, hsCRP, and presence of metabolic syndrome (MS) (p=0.020). In individuals with a predicted 10-yr risk for CHD >or=8% (corresponding with the highest quartile), compared to those with a predicted 10-yr risk <8%, the odds ratio (OR), adjusted for age, platelet count, hsCRP, and hypertension, was 3.3 (1.2-8.9) and adjusted for age, platelet count, hsCRP, and MS, was 4.5 (1.6-11.8). The age-, platelet count-, hsCRP- and hypertension-adjusted OR for a 10-yr CHD risk score >or=8% was 0.8 (0.5-1.3) for hsCRP and 3.9 (1.6-9.4) for hypertension. The age-, platelet count-, hsCRP- and MS -adjusted OR for a 10-yr CHD risk score >or=8% was 0.7 (0.4-1.2) for hsCRP and 7.9 (2.6-24.5) for MS. CONCLUSION: Elevated PDMPs are associated with the 10-yr CHD risk score in healthy men. |
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Authors:
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Tetsuya Ueba; Shosaku Nomura; Norihito Inami; Tomofumi Nishikawa; Motohiro Kajiwara; Ryoichi Iwata; Kohsuke Yamashita |
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Publication Detail:
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Type: Journal Article Date: 2010-04-07 |
Journal Detail:
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Title: Journal of atherosclerosis and thrombosis Volume: 17 ISSN: 1880-3873 ISO Abbreviation: J. Atheroscler. Thromb. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-05-10 Completed Date: 2010-08-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9506298 Medline TA: J Atheroscler Thromb Country: Japan |
Other Details:
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Languages: eng Pagination: 342-9 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Kishiwada City Hospital, Osaka, Japan. a.fenton@liverpool.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Blood Coagulation / physiology Blood Platelets / metabolism* C-Reactive Protein / metabolism Cell-Derived Microparticles* Coronary Disease / blood*, etiology Cross-Sectional Studies Enzyme-Linked Immunosorbent Assay Humans Hypertension / blood, complications Male Metabolic Syndrome X / blood, complications Middle Aged Platelet Glycoprotein GPIb-IX Complex / metabolism* Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Platelet Glycoprotein GPIb-IX Complex; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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