Document Detail


Plasma inflammatory and vascular homeostasis biomarkers increase during human pregnancy but are not affected by oily fish intake.
MedLine Citation:
PMID:  22623389     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Salmon in Pregnancy Study investigated whether the increased consumption of (n-3) long-chain PUFA (LC-PUFA) from farmed Atlantic salmon affects immune function during pregnancy and atopic disease in neonates compared with a habitual diet low in oily fish. In this context, because the ingestion of (n-3) LC-PUFA may lower the concentrations of inflammatory biomarkers, we investigated whether the consumption of oily fish affects the levels of inflammatory cytokines and vascular adhesion factors during pregnancy. Pregnant women (n = 123) were randomly assigned to continue their habitual diet (control group, n = 61), which was low in oily fish, or to consume two 150-g salmon portions/wk (salmon group, n = 62; providing 3.45 g EPA plus DHA) from 20 wk of gestation until delivery. Plasma inflammatory cytokines and vascular adhesion factors were measured in maternal plasma samples. Inflammatory biomarkers, including IL-8, hepatocyte growth factor, and monocyte chemotactic protein, increased over the course of pregnancy (P < 0.001), whereas plasma matrix metalloproteinase 9, IL-6, TNFα, and nerve growth factor concentrations were not affected. Vascular homeostasis biomarkers soluble E-selectin, soluble vascular adhesion molecule-1, soluble intercellular adhesion molecule (sICAM)-1, and total plasminogen activator inhibitor-1 increased as pregnancy progressed (P < 0.001). The plasma sICAM-1 concentration was greater in the control group than in the salmon group at wk 20 (baseline) and 38 (P = 0.007) but there was no group x time interaction, and when baseline concentration was used as a covariate, the groups did not differ (P = 0.69). The remaining biomarkers analyzed were similar in both groups. Therefore, although some inflammatory and vascular homeostasis biomarkers change during pregnancy, they are not affected by the increased intake of farmed salmon.
Authors:
Cruz E García-Rodríguez; Josune Olza; Concepción M Aguilera; María D Mesa; Elizabeth A Miles; Paul S Noakes; Maria Vlachava; Lefkothea-Stella Kremmyda; Norma D Diaper; Keith M Godfrey; Philip C Calder; Angel Gil
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2012-05-23
Journal Detail:
Title:  The Journal of nutrition     Volume:  142     ISSN:  1541-6100     ISO Abbreviation:  J. Nutr.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-21     Completed Date:  2012-08-30     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1191-6     Citation Subset:  IM    
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00801502
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MeSH Terms
Descriptor/Qualifier:
Adult
Animals
Biological Markers / blood
Blood Vessels / drug effects*,  metabolism
Cytokines / blood
Diet*
Dietary Fats / pharmacology*
Docosahexaenoic Acids / pharmacology
Eicosapentaenoic Acid / pharmacology
Female
Fish Oils / pharmacology*
Homeostasis
Humans
Infant, Newborn
Inflammation / blood*
Inflammation Mediators / blood*
Intercellular Adhesion Molecule-1 / blood
Pregnancy / blood*
Salmon
Seafood
Grant Support
ID/Acronym/Agency:
MC_UP_A620_1017//Medical Research Council
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Cytokines; 0/Dietary Fats; 0/Fish Oils; 0/Inflammation Mediators; 126547-89-5/Intercellular Adhesion Molecule-1; 25167-62-8/Docosahexaenoic Acids; AAN7QOV9EA/Eicosapentaenoic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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