| Plasma homocysteine levels and major depressive disorders in Alzheimer disease. | |
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MedLine Citation:
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PMID: 20808087 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: The main aim of this study was to examine the symptomatology of major depression in Alzheimer disease (AD) and its relationship with plasma homocysteine level. METHODS: Eighty-three patients with AD were enrolled for clinical assessments and examination of fasting plasma homocysteine. Diagnosis of major depression was made, and the severity of the depression was assessed. RESULTS: The moderate dementia patients presented with more common behavioral disturbances related to major depression than mild dementia patients. Major depression in patients with moderate AD was associated with higher plasma homocysteine levels. Furthermore, a high plasma homocysteine level was positively associated with behavioral disturbance among study participants with major depression. CONCLUSION: More behavioral disturbance associated with major depression occurred as the dementia progressed. Patients with a higher level of plasma homocysteine presented with a higher behavioral disturbance symptomatology. This finding may account for the relationship between elevated homocysteine levels and depression only in patients with moderate AD. |
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Authors:
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Cheng-Sheng Chen; Mei-Chuan Chou; Yi-Chun Yeh; Yuan-Han Yang; Chiou-Lian Lai; Cheng-Fang Yen; Ching-Kuan Liu; Yi-Cheng Liao |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry Volume: 18 ISSN: 1545-7214 ISO Abbreviation: Am J Geriatr Psychiatry Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9309609 Medline TA: Am J Geriatr Psychiatry Country: United States |
Other Details:
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Languages: eng Pagination: 1045-8 Citation Subset: IM |
Affiliation:
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Departments of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Taiwan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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