| Plasma HMW fibrinogen in patients with ischaemic heart disease. | |
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MedLine Citation:
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PMID: 2353165 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fibrinogen has been reported to be a risk factor for development of myocardial infarction in patients with ischaemic heart disease. The functional properties of plasma high molecular weight (HMW) fibrinogen would suggest that this fibrinogen species is responsible for the association. In a prospective study with a follow-up period of 6 years the plasma concentrations of clottable fibrinogen and of HMW fibrinogen were related to the subsequent development of myocardial infarction in 53 patients admitted with ischaemic heart disease. Neither the concentrations of clottable fibrinogen nor of HMW fibrinogen in the 25 patients developing myocardial infarction deviated from the concentrations in the 28 patients with an uncomplicated course. A significant positive correlation between the concentrations of clottable fibrinogen and of HMW fibrinogen (rs = 0.58, p less than 0.001) suggests that HMW fibrinogen represents a major fraction of the clottable fibrinogen concentration in patients with ischaemic heart disease. |
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Authors:
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S Munkvad; W Nieuwenhuizen; J Jespersen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Scandinavian journal of clinical and laboratory investigation Volume: 50 ISSN: 0036-5513 ISO Abbreviation: Scand. J. Clin. Lab. Invest. Publication Date: 1990 May |
Date Detail:
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Created Date: 1990-07-16 Completed Date: 1990-07-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0404375 Medline TA: Scand J Clin Lab Invest Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 347-9 Citation Subset: IM |
Affiliation:
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Department of Clinical Chemistry, Ribe County Hospital, Esbjerg, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Coronary Disease / blood*, complications Fibrinogen / metabolism* Humans Middle Aged Molecular Weight Myocardial Infarction / blood, etiology Prospective Studies |
| Chemical | |
Reg. No./Substance:
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9001-32-5/Fibrinogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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