Document Detail

Plasma HER2 levels are not associated with cardiac function or hypertrophy in control subjects and heart failure patients.
MedLine Citation:
PMID:  19540604     Owner:  NLM     Status:  MEDLINE    
A proper interaction between the endocardial-derived ligand Neuregulin-1 and the myocardial "Human Epidermal growth factor Receptor 2" (HER2) is essential for maintaining heart function. The shed extracellular domain (ECD) of HER2 circulates in blood and serves as a surrogate marker for breast cancer. Altered cardiac loading conditions are accompanied by dysregulation of the myocardial HER2 gene expression. We studied 193 controls with preserved ejection fraction (EF>55%) and 572 patients with different degrees of systolic heart failure: 98 had EF 45-55%, 138 patients EF 35-44%, and 336 patients, EF <35%, respectively. The corresponding mean HER2 levels were 6.44 ± 0.46 ng/mL, 6.07 ± 0.76 ng/mL and 6.57 ± 0.87 ng/mL, and 6.17 ± 0.71 ng/mL, respectively. Furthermore, there was no significant association between plasma HER2 levels and left ventricular filling pressures or the left ventricular wall thickness. The HER2 plasma levels do not reflect the cardiac function and are therefore not useful as a biomarker for heart failure.
Maximilian G Posch; Anna Panek; Andrea Kersten; Santhosh Kumar Ghadge; Christian Geier; Silke Richter; Andreas Perrot; Mudather Gailani; Rainer Dietz; Diana Lüftner; Cemil Ozcelik
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Publication Detail:
Type:  Comparative Study; Letter     Date:  2009-06-21
Journal Detail:
Title:  International journal of cardiology     Volume:  145     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-05     Completed Date:  2011-09-23     Revised Date:  2012-10-12    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  105-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2009 Elsevier Ireland Ltd. All rights reserved.
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MeSH Terms
Biological Markers / blood
Heart Failure / blood*,  physiopathology
Heart Function Tests*
Hypertrophy, Left Ventricular / blood*,  physiopathology
Middle Aged
Receptor, erbB-2 / blood*
Reg. No./Substance:
0/Biological Markers; EC protein, human; EC, erbB-2

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