Document Detail

Plasma ghrelin and obestatin levels are increased in spontaneously hypertensive rats.
MedLine Citation:
PMID:  19944125     Owner:  NLM     Status:  MEDLINE    
Obestatin, encoded by the same gene as ghrelin, was first described as a physiological opponent of ghrelin. We investigated fasting plasma ghrelin and obestatin levels in spontaneously hypertensive rats and Wistar-Kyoto rats. We found that ghrelin levels, obestatin levels and the ratio of ghrelin to obestatin were significantly higher in spontaneously hypertensive rats than Wistar-Kyoto rats. Systolic blood pressure and diastolic blood pressure were positively correlated; however, heart period and baroreflex sensitivity were negatively correlated with ghrelin levels. Systolic blood pressure was positively correlated, whereas baroreflex sensitivity was negatively correlated with obestatin levels. In addition, systolic blood pressure was a significantly independent variable of ghrelin levels, obestatin levels, and the ghrelin to obestatin ratio in a multiple regression analysis. Our data suggests that there is a disturbance of ghrelin and obestatin in the circulation of spontaneously hypertensive rats and the ghrelin/obestatin system might play a role in blood pressure regulation.
Zhao-Feng Li; Zhi-Fu Guo; Jiang Cao; Jian-Qiang Hu; Xian-Xian Zhao; Rong-Liang Xu; Xin-Miao Huang; Yong-Wen Qin; Xing Zheng
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-11-26
Journal Detail:
Title:  Peptides     Volume:  31     ISSN:  1873-5169     ISO Abbreviation:  Peptides     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-04-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  United States    
Other Details:
Languages:  eng     Pagination:  297-300     Citation Subset:  IM    
Copyright Information:
(c) 2009 Elsevier Inc. All rights reserved.
Department of Cardiology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
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MeSH Terms
Blood Pressure / physiology
Body Weight / physiology
Ghrelin / blood*
Heart Rate / physiology
Hypertension / blood*,  physiopathology
Peptide Hormones / blood*
Rats, Inbred SHR
Rats, Inbred WKY
Reg. No./Substance:
0/Ghrelin; 0/Peptide Hormones; 0/obestatin, rat

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