| Plasma GLP-2 levels and intestinal markers in the juvenile pig during intestinal adaptation: effects of different diet regimens. | |
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MedLine Citation:
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PMID: 15573929 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Adaptation of the residual small bowel following resection is dependent on luminal and humoral factors. We aimed to establish if circulating levels of glucagon-like peptide (GLP-2) change under different dietary regimens following resection and to determine if there is a relationship between plasma GLP-2 levels and markers of intestinal adaptation. Four-week-old piglets underwent a 75% proximal small bowel resection (n = 31) or transection (n = 14). Postoperatively they received either pig chow (n = 14), nonpolymeric (elemental) infant formula (n = 7), or polymeric infant formula alone (n = 8) or supplemented either with fiber (n = 6) or with bovine colostrum protein concentrate (CPC; n = 10) for 8 weeks until sacrifice. Plasma GLP-2 levels were measured at weeks 0, 2, 4, and 8 postoperatively. In addition, end-stage parameters were studied at week 8 including weight gain, ileal villus height, crypt depth, and disaccharidase levels. Plasma GLP-2 levels were higher in resected animals compared to transected animals fed the same diet. Plasma GLP-2 levels were significantly increased in the colostrum protein isolate-supplemented animals following resection compared to all other diet groups. The increase in plasma GLP-2 (pM) was greatest in the first 2 weeks postresection (week 0, 15.5; week 2, 30.9), followed by a plateau at weeks 2 to 4 and a decrease in GLP-2 levels from week 4 to week 8. At week 8, no relationships were found between the plasma GLP-2 levels and the measurements of weight gain, villus height, lactase, sucrase, maltase, crypt depth, or villus/crypt ratio. Plasma GLP-2 levels increase in the first weeks following massive small intestinal resection. The increase in plasma GLP-2 levels was enhanced by supplementation of the diet with CPC. The changes in GLP-2 levels observed in this study may suggest that GLP-2 plays a role in the adaptive response in the intestine following resection in this preclinical model. |
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Authors:
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Monique C Paris; Peter J Fuller; Bendix Carstensen; Eva Nagy; Russell G Taylor; Magdy Sourial; Jens J Holst; Bolette Hartmann; Julie E Binesm |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Digestive diseases and sciences Volume: 49 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2004-12-02 Completed Date: 2004-12-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: United States |
Other Details:
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Languages: eng Pagination: 1688-95 Citation Subset: AIM; IM |
Affiliation:
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Department of Gastroenterology and Clinical Nutrition, Royal Children's Hospital, Parkville, Victoria, Australia. monique.paris@mcri.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological
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physiology* Animals Diet* Dietary Supplements Disease Models, Animal Energy Intake Female Glucagon-Like Peptide 2 Glucagon-Like Peptides Intestine, Small / physiology*, surgery Peptides / blood* Postoperative Period Short Bowel Syndrome / blood, physiopathology Swine |
| Chemical | |
Reg. No./Substance:
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0/Glucagon-Like Peptide 2; 0/Peptides; 62340-29-8/Glucagon-Like Peptides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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